Arcus Biosciences

Arcus Biosciences ( is a biotech company focused on immuno-oncology with clinical stage drug candidates in both monoclonal antibody and small molecule areas.. Be a passionate, creative, and collaborative member of the Small Molecule Dug Substance Development and Manufacturing team that strives to create the best process to support Arcus small molecule pipeline from preclinical development to commercial launch.. Provide person-in-plant support for manufacturing at CMO sites as needed by traveling either domestically or overseas.. Well trained in modern synthetic organic chemistry, including synthetic methodology, reaction mechanism, modern analytical methods (NMR, MS and HPLC).. Maintain broad up-to-date knowledge of current synthetic organic chemistry field as well as industrial trends through scientific literature and participation in conferences.

manufacturing

Description Scientist, Small-Molecule Drug Substance Development Arcus Biosciences (https://arcusbio.com/) is a biotech company focused on immuno-oncology with clinical stage drug candidates in both monoclonal antibody and small molecule areas. Our Small Molecule Drug Substance Development and Manufacturing team has an opportunity for Scientist position to support our small molecule drug development pipeline. Position Description <ul><li>Be a passionate, creative, and collaborative member of the Small Molecule Dug Substance Development and Manufacturing team that strives to create the best process to support Arcus small molecule pipeline from preclinical development to commercial launch.</li><li>Develop efficient, phase appropriate synthetic processes for APIs through effective lab scale R&D, which will include but not limited to route design, route scouting and process optimization toward suitable API synthesis for development and commercial production. Design and execute critical experiments to trouble shoot process issues encountered in large scale productions. Conduct critical experiments to support process characterization and process validation. </li><li>Work in a team of Arcus scientists and partner contract development and manufacturing organization teams to develop efficient manufacturing processes for small molecule drug substance preparation under GMP. The projects may encompass clinical stage candidates through commercial launch. Responsibilities will range from initiating process transfer, through scale up, GMP manufacturing and process validation activities.</li><li>Provide technical review of master batch records.</li><li>Provide person-in-plant support for manufacturing at CMO sites as needed by traveling either domestically or overseas.</li><li>Provide concise technical updates to the Small Molecule Dug Substance Development and Manufacturing organization and key stakeholders in partner functions.</li><li>Partner with Drug Product, Analytical Sciences, Quality Control and Quality Assurance to help ensure Arcus' manufactured GMP drug substances are delivered on time with appropriate quality.</li><li>Contribute to writing / reviewing CMC sections of regulatory filings as needed.</li></ul> Position Requirements <ul><li>Ph.D. in Organic Chemistry or 3 years related experience with M.S. degree and 5 years with B. S. degree.</li><li>Well trained in modern synthetic organic chemistry, including synthetic methodology, reaction mechanism, modern analytical methods (NMR, MS and HPLC). Maintain broad up-to-date knowledge of current synthetic organic chemistry field as well as industrial trends through scientific literature and participation in conferences.</li><li>Proven ability to carry out independent in-depth research in the areas of design and implementation of efficient synthetic routes for complex target organic compounds and/or development of new synthetic methodologies. Established track record for strategic thinking and creative problem solving. A good publication record is desirable.</li><li>Excellent interpersonal skills, including clear, succinct, and timely oral and written communications. </li><li>Proven ability to foster collaborative relationships with key stakeholders. </li><li>Excellent organizational skills, with ability to successfully manage multiple priorities. </li></ul> This role will be based at our Hayward, CA location. The anticipated salary range for fully qualified candidates applying for this position is $135,000 - $150,000 USD annually. This salary range is an estimate of what we reasonably expect to pay for this posted position. The actual salary may vary based on various factors including, without limitation, individual education, experience, tenure, skills and abilities, internal equity and alignment with market data. In addition to a competitive market-based salary, Arcus offers the opportunity to participate in stock programs, a performance-based bonus, and a comprehensive benefits package. Additional information about our total rewards program can be found here: https://arcusbio.com/careers. Arcus Biosciences is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Arcus is committed to the principle of equal employment opportunity for all employees and does not discriminate based on race, religion, color, sex, gender identify, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status or any other legally protected status. EOE/AA/Vets #LI-JC1

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