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- Despite the importance of detecting, quantifying and sequencing RNAs to exploit their roles in biology and medicine, the field of RNA research remains limited by the tools available for monitoring and manipulating RNA.
- An enzyme called reverse transcriptase (RT) is the most foundational tool for converting RNA into cDNA, enabling sensitive detection and RNA sequencing.
- Discovered by the Pyle Lab at Yale University, MRT is an exceptionally processive RT that copies kilobase-length RNAs in a single pass without inhibition by secondary structures or repeats within an RNA template.
- Research Scientist | Molecular Biology
- Enzyme engineering using rational design and directed evolution
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