Brigham and Womens Hospital

Responsibilities will include development and in vitro evaluation of drug delivery formulations - namely small molecule therapeutics and mRNA nanomedicines - and devices (~50% effort), and support preclinical evaluation of technologies in small and large animal models (~50% effort).. The ideal candidate will have experience in working with laboratory animals, and experience in one or more of the following areas: molecular biology, pharmacology, pharmaceutical sciences, and/or biomedical engineering.. B.S./B.A. in a relevant scientific field (e.g., molecular biology, pharmaceutical sciences, pharmacology, biomedical engineering);. Experience with molecular biology assays (ELISA, PCR, protein expression, phage display, next-gen sequencing, cell culture);. Experience with analytical methods (HPLC, LC-MS, SPR, XRD, CD, ICP);

research engineer

GENERAL SUMMARY:
The Research Engineer II will join the Traverso lab at Brigham and Women's Hospital to support translational development of novel therapeutic technologies. The lab consists of a multidisciplinary team of engineers, scientists and physicians focused on preclinical and translational development of drug delivery technologies that push the boundaries of medicine.
Responsibilities will include development and in vitro evaluation of drug delivery formulations - namely small molecule therapeutics and mRNA nanomedicines - and devices (~50% effort), and support preclinical evaluation of technologies in small and large animal models (~50% effort). The ideal candidate will have experience in working with laboratory animals, and experience in one or more of the following areas: molecular biology, pharmacology, pharmaceutical sciences, and/or biomedical engineering. This a one-year term position with the possibility of extension.
Principal Duties and Responsibilities
* Plan and execute experimental protocols to design, manufacture, and characterize new drug formulations and drug delivery technologies;
* Plan and execute pharmacokinetic, biocompatibility, and toxicity assessment of drug formulations and drug delivery devices in small and large preclinical animal models;
* Analyze experimental results using statistical methodology;
* Summarize, document, and present research findings;
* Active involvement in animal model development and refinement;
* Training and mentoring of research technicians, and research staff;
* Procurement of lab supplies and record-keeping;
* Ensure safety standards/procedures are followed, prepare lab for inspections, and correct problems;
* Communicate, interpret, and provide training on lab policies.
Qualifications
* B.S./B.A. in a relevant scientific field (e.g., molecular biology, pharmaceutical sciences, pharmacology, biomedical engineering);
* Two years of prior experience working in a laboratory environment (which may include experience gained at the undergraduate level);
* One year of prior experience working with small or large animal models;
* Demonstrated commitment to producing accurate and high-quality data;
* Experience operating and maintaining technical instruments/equipment;
* Comfort summarizing, reporting and presenting results to researchers;
* Strong organizational, time management and documentation skills;
* Willingness to learn new scientific tools and techniques;
* Ability to work independently and as part of a team;
* Awareness of basic safety issues and ability to follow safety procedures and maintain a safe work environment.
Skills/ Abilities/ Competencies Required
* Experience with molecular biology assays (ELISA, PCR, protein expression, phage display, next-gen sequencing, cell culture);
* Experience with analytical methods (HPLC, LC-MS, SPR, XRD, CD, ICP);
* Experience in drug formulation and characterization;
* Experience working with laboratory animals;
* Travel within the greater Boston area will be required.<br/><br/>#J-18808-Ljbffr

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