Bristol Myers Squibb

The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents.. Priority will be given to candidates experienced in additional stages upstream and downstream of the production process including but not limited to protein engineering, vector design, quality attribute generation, and functional characterization of biotherapeutics.. + Serve as subject matter expert in mammalian vector design for therapeutic production in high-throughput through stable cell line development activities. + Experience in successfully supporting a robust biotherapeutic production pipeline through various roles in protein production and/or analytics including HPLC and LCMS approaches is desired. + Hand-on experience with high throughput molecular biology methods, cloning, plasmid preparation, vector design, PCR, mutagenesis, and DNA sequence analysis is highly desirable

principal scientist

<p>**Working with Us**
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.
Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.
We are seeking an energetic and versatile protein scientist to join our Protein Production and Quality Attributes group. The ideal candidate is experienced with state-of-the-art approaches for high-throughput biotherapeutic production of antibodies, multi specifics, fusion proteins, and recombinant proteins. You will lead and manage the high-throughput production team supporting the BMS biotherapeutic pipeline from the bench in this lab facing role. Your hands on expertise with varied high throughput liquid handing platforms applied to protein production at various scales and technologies for production is essential for success. Priority will be given to candidates experienced in additional stages upstream and downstream of the production process including but not limited to protein engineering, vector design, quality attribute generation, and functional characterization of biotherapeutics. The candidate will have additional opportunities to serve as representative to project teams operating within BMS's thematic research centers.
**Position Responsibilities:**
+ Provide laboratory leadership and management of the high-throughput production group in Cambridge from this bench facing role
+ Expand group capabilities though maintaining a working knowledge a state-of-the-art approaches for high throughput production and facilitating their internal implementation
+ Serve as the point of contact on across discovery biotherapeutics on high-throughput approaches for biotherapeutic production including managing requests, analyzing, communicating results, and cataloging of all data in relevant databases
+ Collaborate with multiple project teams across each thematic research area to advise on key fit-for-purpose production and quality attributes of biotherapeutic purity in line with the needs of the program and stage of development
+ Serve as subject matter expert in mammalian vector design for therapeutic production in high-throughput through stable cell line development activities
+ Enable the timely progression of BMS's discovery pipeline
+ Collaborate with cross functional project drive the discovery and development of next-generation biotherapeutics
+ Independently conceive and execute novel approaches for high-throughput production of biotherapeutics
+ Prepare and present data and updates to project and functional teams, official reports and SOPs for internal and external purposes, internal documents/reports for regulatory filings
+ Manage lab/equipment organization and maintenance.
+ Coordinate and serve as point of contact for CROs in outsourced workflows for gene synthesis
**Basic Qualifications:**
Bachelor's Degree with 8+ years of academic / industry experience
Or
Master's Degree with 6+ years of academic / industry experience
Or
PhD with 4+ years of academic / industry experience
**Preferred Qualifications:**
+ PhD and 4+ years of expertise in theory, equipment, and implementation of high throughput approaches for production of monoclonal antibodies, multispecifics and other modalities is essential
+ Experience in successfully supporting a robust biotherapeutic production pipeline through various roles in protein production and/or analytics including HPLC and LCMS approaches is desired
+ Previous experience managing teams engaged in pipeline support is critical for the successful candidate
+ Hand-on experience with high throughput molecular biology methods, cloning, plasmid preparation, vector design, PCR, mutagenesis, and DNA sequence analysis is highly desirable
+ Familiarity with sequence based, structure based, and predictive approaches for protein design of therapeutics and antigens is desirable
+ Must be very detail-oriented and organized, with excellent time-management and multitasking skills to enable work on multiple pipeline projects
+ Have outstanding analytic and problem-solving abilities
+ Display excellent verbal and written communication, interpersonal and presentation skills, as well as the ability to interact tactfully and effectively with employees at all levels of the organizational structure
+ Must be highly self-motivated, detail-oriented, well organized and work effectively as part of a team
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
**Uniquely Interesting Work, Life-changing Careers**
With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
**On-site Protocol**
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
**Company:** Bristol-Myers Squibb
**Req Number:** R1582722
**Updated:** 2024-07-08 04:15:23.612 UTC
**Location:** Cambridge Crossing-MA
Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.</p>

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