Bristol - Myers Squibb Company

But working at Bristol Myers Squibb is anything but usual.. Provide separation science research and support for the Process Chemistry and Development (CPD) department at BMS in New Jersey, primarily in Summit (SMW) but also in New Brunswick (NBR) based on project needs.. Develop and execute purification processes for payload-linker molecules to support ADC/IMC process development and produce pre-clinical supplies. Familiarity with Affinity chromatography, lyophilization, and size exclusion chromatography. Experience using Berger, Shimadzu, Waters, and Sepiatec equipment is a plus, expectation is a familiarity with these systems

principal scientist

Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. Our Chemical Process Development group is a team of organic chemists, analytical chemists, and chemical engineers working together to design novel syntheses from raw materials to supply new medicines to patients. Our scientists focus on developing safe, economical, sustainable, and robust processes to support clinical trials and the launch of new medicines across various drug modalities including small molecules, peptides, oligonucleotides, and antibody drug conjugates. The work is driven by innovative science, data-driven decision-making, and collaborative teamwork. The scientific knowledge package from the manufacturing process, design parameters, and control strategies enables regulatory filings to bring these novel medicines to patients worldwide. In the role as a Principal/Senior Principal Scientist within the Separation and Enabling Technologies Group, the ideal candidate will: <ul><li>Provide separation science research and support for the Process Chemistry and Development (CPD) department at BMS in New Jersey, primarily in Summit (SMW) but also in New Brunswick (NBR) based on project needs.</li><li>Interact closely with a team of scientists and engineers, including external service providers, to deliver both GMP and non-GMP separations solutions</li><li>Develop chromatography methods for chiral and achiral separation at both analytical and preparative scale.</li><li>Use both preparative liquid chromatography (HPLC) and preparative supercritical fluid chromatography (SFC) to achieve achiral and chiral separations at milligram to gram to kilogram scales</li><li>Develop and execute purification processes for payload-linker molecules to support ADC/IMC process development and produce pre-clinical supplies</li><li>Work with other Separations team members to ensure that the equipment infrastructure is fully operational, and to troubleshoot problems as they arise.</li><li>Influence the strategic plan for separation science in CPD, and to identify and complete continuous improvement projects that may include chromatography method development, infrastructure improvements, IT and process improvements, quality improvements, etc. </li><li>Apply scientific and/or technical skills and functional knowledge and experience to conduct research in Separations</li><li>Work collaboratively within the Separations and Enabling Technologies team, as well as with Project Teams, and Structure Elucidation Scientists (ISE), CPD-Analytical, solid-state groups, and with the Discovery Separations team</li><li>Document purification methods and analytical results in standardized reports to be delivered to project teams as well as to external collaborators and internal or external manufacturing teams</li><li>Contribute to initiatives related to continuous improvement or development of new approaches/Technologies</li><li>Participate in discussions and makes presentations in multidisciplinary meetings, logically presenting information to convey clear, key messages to advance projects in our pipeline</li></ul> Basic Qualifications: <ul><li>Bachelor's Degree and 9 - 12 years of academic/industry experience or Master's Degree and 6-9 years of academic/industry experience or Ph.D. or equivalent advanced degree in the Life Sciences and 4-6 years of academic/industry experience</li></ul> Preferred Qualifications: <ul><li>Experience in analysis and preparative purification of small molecules by HPLC and SFC</li><li>Demonstrated proficiency in chiral separation by supercritical fluid chromatography (SFC) and HPLC</li><li>Familiarity with containment principles and personal-protection practices associated with potent compounds</li><li>Experience in a high throughput environment managing samples and associated data</li><li>Experience in UV, MS and CD spectroscopy</li><li>Familiarity with Ion Exchange Chromatography</li><li>Familiarity with Affinity chromatography, lyophilization, and size exclusion chromatography</li><li>Experience operating in a GMP environment</li><li>Demonstrated problem-solving skills, including troubleshooting processes, instruments, and data management issues</li><li>Proficiency in scientific/technical writing including report summaries</li><li>Experience using Berger, Shimadzu, Waters, and Sepiatec equipment is a plus, expectation is a familiarity with these systems</li><li>Familiarity with AKTA purification systems, and TFF and other membrane technologies</li><li>Familiarity with Process Analytical Technologies is a plus</li><li>Experience with MassLynx, Chromescope, ProNTo, Empower, LabSolutions, ChemStation is a plus</li><li>Mastery of ChemDraw, MS Office, and ELN is required</li></ul> Why You Should Apply Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as "Transforming patients' lives through science™ ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

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