Amgen Inc

Principal Scientist - Clinical Pharmacology. Amgen Clinical Pharmacology Modeling and Simulation (CPMS) is seeking a Principal Scientist in our Thousand Oaks, CA location.. The Principal Scientist will support Amgen clinical development and translational sciences programs across multiple therapeutic areas with emphasis on oncology.. Building pharmacostatistical models to support Population Pharmacokinetics/Pharmacodynamic (PKPD) and exposure-response analyses using relevant state of the art modeling and simulation techniques.. Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 2 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience

principal scientist

JOB ID: R-184114 LOCATION: US - California - Thousand Oaks WORK LOCATION TYPE: On Site DATE POSTED: Mar. 08, 2024 CATEGORY: Research SALARY RANGE: 135,729.00 USD - 168,454.00 USD
HOW MIGHT YOU DEFY IMAGINATION?
If you feel like you're part of something bigger, it's because you are. At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies. We are global collaborators who achieve together-researching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. It's time for a career you can be proud of.
Principal Scientist - Clinical Pharmacology
Live
What you will do
Let's do this. Let's change the world. Amgen Clinical Pharmacology Modeling and Simulation (CPMS) is seeking a Principal Scientist in our Thousand Oaks, CA location. As part of the Clinical Pharmacology, Modeling and Simulation department, the Modeling and Simulation. The Principal Scientist will support Amgen clinical development and translational sciences programs across multiple therapeutic areas with emphasis on oncology.
<h3>Key responsibilities include</h3>
<ul>
<li>Building pharmacostatistical models to support Population Pharmacokinetics/Pharmacodynamic (PKPD) and exposure-response analyses using relevant state of the art modeling and simulation techniques.</li>
<li>Training in binary and categorical and binary data analyses, time-to-event (hazard) models, Poisson models, MCMC and Bayesian methods as applied to exposure-response analyses and Population PK and PKPD analysis.</li>
<li>Perform meta-analysis using proprietary and/or literature data.</li>
<li>Participate in cross-functional project teams and provide scientific input for dose selection, early and late phase study designs using modeling and simulation inputs.</li>
<li>Contribute to clinical pharmacology strategy for the program(s) and implement project plans.</li>
<li>Generate modeling reports and contribute to the summary documents for regulatory submissions.</li>
</ul>
Win
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications.
<h3>Basic Qualifications</h3>
Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 2 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience
Or
Master s degree and 5 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience
Or
Bachelor s degree and 7 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience
<h3>Preferred Qualifications</h3>
<ul>
<li>PhD in Pharmacometrics, Pharmaceutical sciences, Applied Statistics/Mathematics, Biostatistics, and/or Engineering or related fields with equivalent professional degrees (e. g. MD, PharmD) with 3+ years of PK/PD or statistical modeling experience.</li>
<li>3+ years industry or relevant academic experience in pharmacometric analyses, data science, and/or applied biostatistics of small molecules and/or biologics.</li>
<li>Proficiency in modeling software (e. g. NONMEM, R/S-Plus, STAN, Python, SAS, MATLAB)</li>
</ul>
Thrive
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for our teammates' professional and personal growth and well-being.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:
<ul>
<li>Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.</li>
<li>A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan</li>
<li>Stock-based long-term incentives</li>
<li>Award-winning time-off plans and bi-annual company-wide shutdowns</li>
<li>Flexible work models, including remote work arrangements, where possible</li>
</ul>
Apply now
for a career that defies imagination
Objects in your future are closer than they appear. Join us.
careers.amgen.com
Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
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