NEUROCRINE BIOSCIENCES

Supports protein and peptide characterization, purification and conjugation workflows, as needed. Specific methodologies may include capillary electrophoresis, mass spectrometry, differential scanning calorimetry, static or dynamic light scattering, high-pressure liquid chromatography, SDS-PAGE, isoelectric focusing, western blot, surface plasmon resonance, biolayer interferometry. Familiarity with basic techniques in protein and peptide characterization such as SDS-PAGE, isoelectric focusing, western blot, capillary electrophoresis, endotoxin quantification/removal, DSC, DLS, HPLC, SPR, BLI, etc. Evaluates new biochemical methodologies, initiates and support new platform processes, instrumentation and technologies for antibody and peptide expression and characterization. Experience assessing peptide structure, stability and behavior in solution, understanding of antibody protein structure and function

associate scientist

<h3>Who We Are</h3>
At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.
<h3>What We Do</h3>
Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie
<h3>About the Role</h3>
Neurocrine is building a team of talented scientists with proven track records to drive biotherapeutic lead optimization and pipeline progression into the clinic across multiple biologic modalities. The associate scientist/scientist will carry out biochemical and biophysical studies in addition to assisting with purification, conjugation and characterization workflows on therapeutic proteins and peptides under the supervision of senior scientists. The person in this role will also collaborate with colleagues working on gene therapy programs. The ideal candidate will have hands-on experience in characterizing therapeutic proteins and/or peptides, preferably in a biotechnology or pharmaceutical company setting. Level to be commensurate with experience.
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Your Contributions (include, but are not limited to):
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Carries out biochemical and biophysical studies to support scientific activities and project goals, generates data packages to support the advancement of candidate development
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Supports protein and peptide characterization, purification and conjugation workflows, as needed
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Specific methodologies may include capillary electrophoresis, mass spectrometry, differential scanning calorimetry, static or dynamic light scattering, high-pressure liquid chromatography, SDS-PAGE, isoelectric focusing, western blot, surface plasmon resonance, biolayer interferometry
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Evaluate new biochemical methodologies, initiate and support new platform processes, instrumentation and technologies for protein and peptide characterization under the supervision of senior scientists
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Generates and works with complex data sets, with a strong understanding of advanced data analysis and statistical tests
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Prepares detailed data reports and presents results to peers and colleagues
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Other duties as assigned
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<h3>Requirements</h3>
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BS/BA degree and 2 - 4+ years of relevant experience OR
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MS/MA degree and 1 - 3+ years of relevant experience OR
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PhD or equivalent and some relevant experience: may include postdoc experience, this position will require a PhD in a relevant discipline
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Recognizes fundamental anomalies in data points and identifies issues in experiments / processes
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Ability to think beyond the technical process and consider the impact decisions will have on the broader scientific goals
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Strong knowledge of scientific discipline, principles, methods and techniques
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Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools
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Strong computer, problem-solving, and analytical thinking skills
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Detail oriented with ability to manage diverse deadlines and operate in dynamic work environment
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Excellent communication skills with the ability to collaborate with cross-functional scientists
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Familiarity with basic techniques in protein and peptide characterization such as SDS-PAGE, isoelectric focusing, western blot, capillary electrophoresis, endotoxin quantification/removal, DSC, DLS, HPLC, SPR, BLI, etc
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Experience with typical purification processes for antigens, antibodies and therapeutic proteins and/or peptides
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<li>
Evaluates new biochemical methodologies, initiates and support new platform processes, instrumentation and technologies for antibody and peptide expression and characterization
</li>
<li>
Experience assessing peptide structure, stability and behavior in solution, understanding of antibody protein structure and function
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Demonstrated ability to concisely explain experimental processes, interpret and communicate results, identify implications of results and recognize anomalous or inconsistent results
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<h3>LI-AD1</h3>
Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.
We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.
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The annual base salary we reasonably expect to pay is $106,400.00-$154,325.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

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