Charles River Laboratories

Design, troubleshoot, and analyze experiments discovery programs with label-free biosensor analysis. Characterize biotherapeutics by developing biosensor assays to quantitate antibody-target binding (e.g. kinetics, affinities) with high-throughput screens on various biosensor platforms. Performed high-resolution kinetics and affinity analysis of antibody-antigen binding and other protein interactions. Experience with other immunoassay platforms and/or flow cytometry is an asset.. We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development.

research scientist ii

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about. Job Summary We are seeking a Research Scientist II - Protein Sciences for our Discovery site located in South San Francisco, CA.  Serve as scientific team member conducting routine analysis of biotherapeutics in antibody discovery projects. Responsible for providing quantitative analysis, developing new analytical methods and data interpretation of biophysical characterization of protein-protein interactions and immunoassays. Essential responsibilities include: <ul><li>Design, troubleshoot, and analyze experiments discovery programs with label-free biosensor analysis</li><li>Characterize biotherapeutics by developing biosensor assays to quantitate antibody-target binding (e.g. kinetics, affinities) with high-throughput screens on various biosensor platforms </li><li>Perform high-throughput epitope binning experiments</li><li>Performed high-resolution kinetics and affinity analysis of antibody-antigen binding and other protein interactions</li><li>Function as the primary contact for the planning and execution of antibody discovery projects related to research and method development, and for the design, planning, conduct and reporting of experiments. </li><li>Ensure raw data is accurate, complete and in appropriate order to meet protocols and SOP specifications. Prepare high quality final reports appropriate for the project including method development, qualification, and data analysis. </li><li>Provide oversight of the laboratory and mentor junior staff in areas such as protocol interpretation, method development and refinement, troubleshooting, and technique validation. Provide scientific expertise in experimental design, and interpretation. </li><li>Multi-task effectively to triage and manage multiple projects</li><li>Must be able attend and present at scientific meetings with clients. </li></ul>Job Qualifications The following are minimum requirements related to the Research Scientist II position. <ul><li>Education: Bachelor's degree (B.S./B.A.) or Master's degree (M.S./M.A.) in a scientific related discipline. Ph.D. preferred. </li><li>Experience: Minimum of 8 years related experience in academic or biopharmaceutical industry. Minimum of 3 years of hands-on experience with biosensors is essential. Experience with other immunoassay platforms and/or flow cytometry is an asset. </li><li>An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above. </li><li>Other: Strong analytical, troubleshooting and problem-solving skills. Demonstrate leadership skills as they pertain to intra- and interdepartmental initiatives, sponsor interactions, and business development. Effective written and verbal communication skills. Ability to handle multiple projects, prioritize work and meet deadlines. Proficiency in the use of different biosensors and strong understanding of label-free principles is required. Must have hands-on experience with BLI/SPR platforms. </li></ul>The pay range for this position is $111,000-$122,500. Please note that salaries vary within the range based on factors including, but not limited to, experience, skills, education, certifications, and location. About Discovery Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market. About Charles River Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market. With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 86% of the drugs approved by the FDA in 2021. Equal Employment Opportunity Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, or national origin, veteran or disability status. If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to [email protected]. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications. For more information, please visit www.criver.com.

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