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This individual will manage a team of scientists and associates in vaccine antigen identification, screening, and final selection of the lead vaccine candidate through a series of in vitro and in vivo studies and support advancement of the selected candidate to clinical development.
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Experience culturing bacteria, and especially anaerobic bacteria; with protein expression, especially in vitro protein expression; with molecular biology, particularly digital PCR; and with automated liquid handling.
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Immunologist and/or genetics/genomics expert: will analyze genetic variants and their effects on enhancer and promoter function in immune cells in vitro, through performing massively parallel reporter assays and high-throughput CRISPR screens in human primary T cells from IBD patients and healthy controls.
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Work with outside contractors/CROs for conduct of in vitro and/or in vivo studies. Analyze, organize and summarize data from in vitro and in vivo studies. Experience working with CROs for conducting in vitro and in vivo studies.
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Evaluating the functionality of these materials both in vitro and in vivo. Ph. D. in Polymer Chemistry, Pharmaceutics, Chemical Engineering, Bioengineering/Biomedical Engineering, Medicinal Chemistry, or closely related field.
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Work collaboratively with other lab members to execute complex experimental studies of cancer therapeutics including assessments of tumor responses in vitro and in vivo. Experience with tissue culture of primary cells, DNA/RNA isolation, and experience with molecular assays such as DNA/RNA sequencing, RT-PCR, immunohistochemistry, CRISPR gene editing.
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Collaborate with in vivo and in vitro pharmacologists within the Drug Discovery group and interact with cross-functional project teams to interpret and present key data. Collaborate with in vivo and in vitro pharmacologists within the Drug Discovery group and interact with cross-functional project teams to interpret and present key data.
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Seattle Children’s Hospital A/BSL3 Specialist II Seattle , Washington Apply Now Responsibilities:This position is for a specialized individual capable of performing the day-to-day tasks required to operate a safe, successful, and compliant A/BSL-3 research facility with an active in vivo and in vitro program.
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In this role, the successful candidate will be responsible for in vitro cell culture and banking of recombinant and engineered cell lines to support the early research pipeline and ShapeTX's novel RNAfixTM and RNAskipTM technology platforms.
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Support developing assays for formulation characterization in vitro. Bachelor's degree in molecular biology, chemistry, biochemistry, pharmaceutical science, chemical engineering or related field, Master is preferred.
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Perform RNA extraction, qPCR, protein extraction, protein assays, and associated data analysis. As a Research Associate III at Cajal, you will be part of and support the Drug Discovery group, tasked with rapidly inventing and advancing transformative therapies.
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It also has a rapidly developing presence in highly specialised and molecular clinical diagnostic testing and in-vitro diagnostic products. It is one of the market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, advanced material sciences and in the support of clinical studies, as well as having an emerging global presence in Contract Development and Manufacturing Organisations.
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Applying expertise in CRISPR gene editing technology, work with R&D team to develop RNA LNP formulations for customers' early phase drug development project, and carry out in vitro assays to evaluate the formulations' performance.
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I am partnered with a rapidly growing biotechnology company who is looking for an in vitro pharmacology expert to join their team! Perform in vitro pharmacology studies, help in design, execution, and interpret pharmacology data.
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Designs, conducts and/or validates statistical analysis of preclinical in vitro and in vivo experimental data, and assists scientists in making data-driven decisions. Experience with building dashboards, performing biostatistics, preclinical/clinical trial biomarker dataset analysis in R studio, JMPPro, Spotfire to identify, evaluate prognostic/predictive biomarkers.
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vitro job in Seattle, WA
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