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Initiating pre-purification and post-purification analysis of submitted samples by LCMS (liquid chromatography - mass spectrometry). This laboratory-based role will support their high throughput purification workflows by monitoring and maintaining instrument performance, executing sample handling tasks, and managing chemicals and consumables.
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Prior experience in molecular biology and protein expression/purification in an academic or industrial setting. A dedicated scientist who can apply molecular biology and cell culture skills to the design and execution of large-scale macromolecular production to enable multiple drug discovery projects.
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This individual will be responsible for building an internal oligonucleotide chemistry lab and will lead the design, synthesis, purification, and analysis of oligonucleotides and their conjugates.
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Plan and execute studies requiring molecular biology techniques including E. coli cell culture, plasmid preparation, RNA synthesis, and purification with the aim to develop the processes that can be scaled up and transferred to MSAT labs.
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The Scientist, Downstream Process Development in MSAT will work in a matrix team management environment with global engineers and scientists to achieve robust and scalable purification processes to support 2nd generation processes, late-stage programs, and life-cycle management.
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The Separation Sciences group in Discovery Chemistry at our client in Boston, MA is seeking a candidate to join their team whose mission is to analyze and purify novel medicines prepared by their medicinal chemist colleagues.
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Recombinant protein expression and purification Biochemical and cell-based binding/functional assays, and experience with flow cytometry is a plus. Hands-on experience in one or more of the following areas: Molecular cloning, including DNA/RNA extraction, PCR, and Sanger or Next Generation Sequencing.
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Perform purification (anion exchange, reverse phase), analysis (HPLC/UPLC), characterization (LCMS, UV, melting temperature) of oligonucleotides and their conjugates. Strong experience with the operation of oligonucleotide synthesis machinery (Mermade), and AKTA purification unit.
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Complete in-vitro transcription, chromatography and filtration purification, LNP encapsulation, and drug product formulation studies. Complete in-vitro transcription, chromatography and filtration purification, LNP encapsulation, and drug product formulation studies.
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MRNA, DNA, Cell Culture, Bioassay, Molecular Biology, Analytical Development, Process Development, Nucleic Acid Purification, LNP. mRNA, DNA, Cell Culture, Bioassay, Molecular Biology, Analytical Development, Process Development, Nucleic Acid Purification, LNP.
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Ensure development of phase-appropriate drug substance processes for portfolio of bispecific antibodies and cytokine fusion molecules, including cell banking, upstream cell culture, and downstream purification.
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Miscellaneous work related to protein chemistry. We're seeking an Associate Scientist/Scientist in Protein Science to join us in our mission to improve human health and quality of life through the development, distribution, and application of advanced computational methods.
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Provide technical and logistical support to GMP operations in a multi-product cell culture and purification plant. Experience with upstream process development. Solid understanding of computerized systems in biopharmaceutical manufacturing environment, i.e., LIMS, Distributed Control System, Process Data Historian, and MES.
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Experience with molecular biology techniques, such as PCR, DNA purification and quantification methods. We are looking for a highly motivated researcher to join our team as Research Associate/Senior Research Associate, supporting our novel target identification and validation workflow in house, with focus on Next Generation Sequencing.
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Tasks to be completed may include fermentation, protein purification, solvent extractions, tissue culture, preparation of bulk solutions, aseptic fills of buffers, filling and labeling of vials under sterile and non-sterile conditions, routine buffer and media preparation, filtration, vial preparation and sterilization.
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purification job in Natick, MA
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