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Job Title: Associate Scientist II, Downstream Process Development (Contract) Optimize downstream parameters such as purity and yield for unit operations including: depth filtration, membrane filtration, tangential flow filtration, affinity & ion exchange chromatography, and ultracentrifugation.
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Perform routine production activities such as upstream and downstream processing, purification, and formulation. Perform routine production activities such as upstream and downstream processing, purification, and formulation.
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Downstream Marketing Director- HPM Services (Cambridge) Headquartered in the Netherlands and operating in more than 100 countries globally, we focus our advanced technology and deep clinical and consumer insights on Precision Diagnosis, Image Guided Therapy, Enterprise Informatics, Monitoring/ Connected Care, Sleep & Respiratory Care and Personal Health.
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Demonstrated knowledge of cGMP manufacturing with knowledge in manufacturing operations in downstream processing utilizing single use technology (SUT). Demonstrated knowledge of cGMP manufacturing with knowledge in manufacturing operations in downstream processing utilizing single use technology (SUT.
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Job Description The individual will execute relevant protocols to purify therapeutic oligonucleotides suitable for downstream in vivo studies. We are looking for a scientist that possesses a strong background in chemistry or related scientific fields, hand-on experience in oligonucleotide analytical techniques, along with a willingness to learn and collaborate in a fast-paced environment.
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Supervise the execution of pharmacology studies at CROs and perform in-house downstream analysis to support drug discovery program needs. Experience with molecular biology techniques such as DNA and RNA extraction, qPCR, protein quantification, ELISA, and enzymatic assays is required.
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10+ years experience in biologics process development and a strong working knowledge of antibody processing, including upstream and downstream processes. Ensure development of phase-appropriate drug substance processes for portfolio of bispecific antibodies and cytokine fusion molecules, including cell banking, upstream cell culture, and downstream purification.
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Conducts radioligand binding, biochemical and cell-based signaling assays to support the Internal Medicine Research Unit, including in vitro and ex vivo experiments to help characterize novel targets, characterize target engagement and downstream effects of small molecule modulators.
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We have a unique opportunity for a Downstream Global Product Manager to join the Hospital Patient Monitoring (HPM) business and own the commercial product marketing activities for one of the product portfolios.
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Leverage DFM/DFA skills to influence product decisions and communicate the downstream operational impacts of design. The Global Supply Chain Manager will leverage their expertise and leadership to build a supply chain that will ensure the production of 3d printing products that are changing industries and innovating new technologies.
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Collaborating with downstream process development, the candidate will facilitate the implementation of optimized formulations into the processes and monitor the products stability across storage conditions.
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Solid knowledge of upstream and/or downstream, as well as a general knowledge of the associated analytical, and media/buffer preparation techniques. Playing a key role in performing hands on evaluations and forming collaborations both internal to Amgen and with Vendors to advance upstream and downstream processing capabilities.
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Additional skills to support downstream characterization as needed would be beneficial and could include: protein expression and purification using FPLC systems and biophysical characterization methods (SEC-MALS, DSF, and biosensor techniques including BLI and SPR.
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Downstream experience with standard chromatography and/or DNA purification kits is a plus. The Research Production team is responsible for the upstream enzymatic synthesis and downstream manufacturing of drug substance to support pre-clinical trials.
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Analyze upstream and downstream industry landscapes, market trends, industry growth drivers, and competitive activity. As Senior Strategy Manager, you will play a pivotal role in shaping and executing the strategy for our Carbon and Silica Technologies businesses.
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downstream job in Lexington, MA
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