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ResponsibilitiesLead a team of experts and technicians to develop a differentiated LNP-based delivery system for RNACollaborate with the RNA team to conduct in vitro and in vivo studies, leading to eventual clinical trialsImprove upon the current mainstream LNP-based delivery systems, to increase the expression rate, lower the immunogenicity, etc.
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Founded in late 2015, KSQ is a clinical-stage biotech that has rapidly advanced the field of CRISPR-enabled functional genomics, from in vitro cell autonomous screens to more complex genome-scale screens of immune cells in vivo.
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Integrate data to provide a detailed understanding of the pharmacology of therapeutic proteins to enable understanding of in vitro MOAs and in vivo correlates of efficacy. Ampersand is currently seeking an experienced leader with deep expertise in drug development to head our In Vivo Pharmacology team.
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Relevant experience with T cells and other immune cells in vitro and in vivo, immunological techniques, and multicolor flow cytometry are highly desirable. CRISPR, RNA/DNA analyses (RNseq), immunohistochemistry, immunoprecipitation, immunoblotting, and general lab organization/safety.
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Collaborate with members from other functional areas, including medicinal chemistry, in vitro pharmacology, and genetics. Primary responsibilities include contributing to the execution of in vitro experiments including establishing in vitro cell-based model systems and the development of immunoassays to support the identification and validation of novel targets to treat CNS diseases.
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Oversee the design, planning, and execution of preclinical studies, including in vitro and in vivo experiments, to evaluate the efficacy, safety, and mechanism of action of drug candidates. Reporting to and partnering with the CEO, this role will lead a team of talented research scientists in Cancer Biology, Protein Therapeutics, Analytical Development, Pharmaceutical Chemistry, Formulation Development, Process Development and CMC Leadership for our Nemvaleukin alfa, IL-12 and IL-18 R&D programs.
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Proclinical Staffing is seeking an In-Vitro Research Associate to join a leading pharmaceutical company. In-Vitro Research Associate - Contract - Onsite. Design and execute in vitro screens and assays to characterize novel siRNA modifications that impact activity or uptake.
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Lead formulation development of mRNA drug targets entailing: LNP formulations for in vitro/in vivo studies. Work closely and build relationships with select CROs with focus on in vivo studies, drug carrier design/development, assay development.
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Develop RNA purification, characterization, and analytical methods to generate therapeutic grade material for in vitro and in vivo studies. Develop RNA purification, characterization, and analytical methods to generate therapeutic grade material for in vitro and in vivo studies.
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Experience with standard molecular biology techniques such as PCR, bacterial plasmid production, in vitro transcription. Perform experiments to produce DNA templates for in-vitro transcription.
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Perform formulation preparation for various routes of administration to support pre-clinical in vivo or in vitro projects. Interact with the bioanalytical, in vivo teams and customers on scientific study designs, protocols, adverse events, shipping details, and reports.
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This position requires strong pharmacometrics skills combined with biological understanding and assay development skills to enable the team to conduct PK modeling studies.
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Cultivate engagements between Danaher and biopharma key opinion leaders (KOLs) in neurology and related disease areas; possess in depth knowledge of biopharma drug pipelines in neurology and anticipate the diagnostic needs of pharma (from Research Use Only (RUO) to Clinical Trial Assay (CTA) to In Vitro Diagnostics (IVD) inclusive of Companion Diagnostics (CDx) and Lab Developed Tests (LDTs.
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Expertise is required with how RNA secondary structure and topology affects both its generation ( in vitro or in vivo ) and its function. Knowledge of in vitro transcription methods for generating RNAs and familiarity with RNassociated immunogenicity is important.
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Knowledge of the conduct and interpretation of a variety of in vitro DMPK assays. As a BA scientist, you will provide drug discovery and development bioanalytical input and support for the analysis of in vivo PK, PD, and in vivo samples across the global Oncology portfolio.
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vitro job in Cambridge, MA
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