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Lead the design, execution, analysis, interpretation, and report of clinical pharmacology studies (e.g., food effect, BA/BE, human ADME, drug interactions, renal and hepatic impairment, etc.) An advanced degree (PhD, MD, or PharmD) in pharmaceutical sciences, pharmacokinetics, pharmacology, or a closely related scientific discipline plus at least 8 years of pharmaceutical industry experience in clinical pharmacology and/or pharmacometrics with a record of increasing responsibility and independence.
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Lead or Co-lead all quantitative pharmacology activities to support both regulatory filings and internal decision-making (e.g., Exposure-Response, QTc prolongation risk assessment, population PK/PD analysis) by working closely with internal colleagues (i.e. DMPK, toxicology, biology, clinical, statistics) and external vendors to advance programs from Phase I to late-stage development.
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A minimum of 10 years of related pharmaceutical or biotechnology industry experience in clinical pharmacology, population PK, PK-PD modeling, DMPK, and/or pharmacometrics and a proven track record advancing programs through the drug development process, from discovery through IND to registration, informing data driven decisions on dose and schedule, making tough judgement calls where needed.
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The Department of Clinical Pharmacology Modelling and Simulation (CPMS) at GSK is recruiting for an Associate Director/or Director level Quantitative Systems Pharmacologist, with a robust background in Respiratory & Immunology.
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At 1910 Genetics, we put computation at the heart of drug discovery, blending expertise in computational chemistry, structural biology, pharmacology, genetics, data science, and software engineering to develop drugs for previously undruggable targets.
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B.S./B.A. in a relevant scientific field (e.g., molecular biology, pharmaceutical sciences, pharmacology, biomedical engineering); The ideal candidate will have experience in working with laboratory animals, and experience in one or more of the following areas: molecular biology, pharmacology, pharmaceutical sciences, and/or biomedical engineering.
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The Dana-Farber/Boston Children’s Cancer and Blood Disorders Center is seeking a pediatric hematologist/oncologist at the Assistant Professor level with specialization in the area of stem cell transplantation at Boston Children’s Hospital (BCH) and Dana-Farber Cancer Institute (DFCI), with specific expertise in both survivorship and clinical pharmacology.
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The Program Leader will lead a cross-functional team across clinical operations, regulatory affairs, clinical pharmacology, biomarkers, CMC, non-clinical, and medical to deliver against the program strategy.
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Expertise in toxicology/pharmacology and determining health-based exposure limits. A doctoral degree in Toxicology, Pharmacology, or a related field; or a master's/bachelor's degree with significant experience in toxicology/pharmacology.
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Perform in vivo pharmacology research in a matrixed environment, as well as external academic collaborations and an extensive network of CROs. Perform in-vitro assays; including ELISA, ELISpot, Luminex, flow cytometry, and qPCR.
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Previous patent prosecution law firm experience, patent bar membership, and a background in one of the following fields: cell or molecular biology, immunology, biochemistry, bioinformatics, organic chemistry, medicinal chemistry, cancer biology, pharmacology.
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Solid understanding of drug metabolism, bioanalysis, pharmacokinetics, preclinical pharmacology, PK/PD modeling and clinical study designs. Review preclinical study reports, in conjunction with Pharmacokinetics/DMPK and prepare regulatory submission documentation.
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Defining and delivering reporting content for use in managing clinical trial conduct in collaboration with other Clinical Operations and Clinical Data Management roles, Medical Monitors, Translational Medicine, Clinical Pharmacology, Biostatistics, and other internal and external stakeholders.
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Comprehensive understanding of DMPK and pharmacology/safety aspects of drug discovery and development. Having a breadth of influence and impact across AstraZeneca Clinical Pharmacology and externally within their discipline.
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PhD or PharmD in clinical pharmacology, pharmacometrics, or related discipline with at least 7-10 years’ experience in the pharmaceutical and/or biotech industry. Reporting to our SVP, Pharmaceutical Sciences, you will be responsible for the design and implementation of clinical pharmacology aspects of patient trials and NDenabling clinical pharmacology studies.
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pharmacology job in Cambridge, MA
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