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Downstream experience with standard chromatography and/or DNA purification kits is a plus. We are seeking motivated individuals with experience and familiarity with enzymatic synthesis, standard chromatography techniques, TFF, DNA purification kits, and molecular biology techniques such as DNA manipulations including PCR, ligations, restriction digestions, and plasmid cloning.
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This position is a hands-on role, and the successful candidate will have deep knowledge and experience in long oligonucleotide purification and downstream processing to advance our cutting-edge gene editing drug discovery programs.
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The Research Production team is responsible for the upstream enzymatic synthesis and downstream manufacturing of drug substance to support pre-clinical trials. A successful candidate will help with in-house manufacturing of key materials and optimize our production process to support manufacturing DNA gene therapy molecules.
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This position is part of the Downstream Hardware Modality located in Bioprocess and will be fully remote. The Downstream Hardware Field Application Specialist for Cytiva is responsible for providing technical expertise during pre-sales discussions, instrument demonstrations, customer training, post-sales support, seminars, and promotional events.
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Your primary responsibility is to perform hands-on development of purification and characterization methods for nucleic acids such as mRNA and circRNA, with the ultimate goal of generating therapeutic grade material for in-vitro downstream assays and pre-clinical in-vivo studies.
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Perform routine right-first-time cGMP manufacturing of cell and gene therapy products including but not limited to aseptic processing, cell isolation, selection, culturing, cryopreservation, upstream processing, downstream processing, aseptic fill finish and final product visual inspection.
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Perform small-scale purification process including ultracentrifugation, column chromatography, cell lysis, clarification, AKTA and TFF unit operations, and depth filtration for manufacturing of LVV gene therapy vectors across multiple preclinical programs and disease areas to ensure on time delivery.
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Assess oligonucleotide purity by Ultra Performance Liquid Chromatography (UPLC). This role will involve synthesis, downstream processing, and characterization of the synthetic oligonucleotides using state-of-the-art equipment.
$33 an hourExpandUpdated 3 days ago - UpvoteDownvoteShare Job
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Downstream purification of biologics including chromatography separations and filtration operations. essential for success., Cell culture, microbial fermentation, Chromatography design, use of QbD and.
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Apply your proficiency in a diverse range of downstream unit operations, such as chromatography (affinity, ion exchange, HIC, SEC, etc.) As a member of the Arcaea team, you will be responsible for leading Arcaea's downstream process development and scaling up activities.
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Downstream AKTA Protein Purification & Chromatography experience in GMP environment. Develop and optimize downstream processes for the purification of therapeutic proteins, ensuring high yield, purity, and product quality.
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Selling Thermo Fisher's downstream chromatography products (POROS Chromatography and CaptureSelect Affinity resins and columns) into process development and clinical/commercial manufacturing groups within biopharma accounts.
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Strong technical experience in scalable mRNA production encompassing in vitro transcription and purification by chromatography/filtration. Lead an integrated process development team across upstream and downstream functions for mRNA production.
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Sail Biomedicines is seeking a highly motivated and innovative Associate Director, Drug Substance Process Development to be the subject matter expert and leader of RNA manufacturing processes, including upstream and downstream activities.
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Lead right-first-time cGMP manufacturing of cell and gene therapy products including but not limited to aseptic processing, cell isolation, selection, culturing, cryopreservation, upstream processing, downstream processing, aseptic fill finish and final product visual inspection.
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downstream chromatography jobs in Boston, MA
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