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10+ years of experience in biologics process development with a strong understanding of antibody processing, including upstream and downstream processes. Develop phase-appropriate drug substance processes for antibodies and proteins, including cell banking, upstream cell culture, and downstream purification.
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The Associate Director/Director Upstream Process Development and Technical Operations will be directly responsible for the process development and technical manufacturing elements of AVEO’s biologics drug substance programs.
ExpandApply NowActive JobUpdated 8 days ago - UpvoteDownvoteShare Job
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Experience with direct experience in AAV and late-stage molecular biologics development, including participation in projects involving cross-functional teams. from pre-clinical through licensure of viral vectors, gene therapies, and/or molecular biologics.
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The Senior Scientist, Downstream Early Pipeline Development, supports lentivirus (LVV) gene therapy pipeline portfolio, developing a robust platform process for existing and novel LVV pseudotypes/cargo vectors, and building improved process technologies for LVV production.
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Downstream purification of biologics including chromatography separations and filtration operations. responsibility for scientific leadership and technical oversight of upstream and downstream process.
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10+ years experience in biologics process development and a strong working knowledge of antibody processing, including upstream and downstream processes. Ensure development of phase-appropriate drug substance processes for portfolio of bispecific antibodies and cytokine fusion molecules, including cell banking, upstream cell culture, and downstream purification.
ExpandApply NowActive JobUpdated 6 days ago - UpvoteDownvoteShare Job
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Protein Biologics Development experience with proteins refolded from E. coli and proteins expressed in CHO cells with oversight of process development for both upstream and downstream. Experience with Tech transfer to CDMO for non-GMP and GMP manufacturing, including cell line development, process development, analytical method development and manufacturing scale up.
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Situated at the junction of high throughput screening, fermentation, and downstream processing, our team plays a pivotal role in characterizing engineered strains, target biomolecules, and processes crucial to Ginkgo's mission of making biology easier to engineer.
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Sail Biomedicines is seeking a highly motivated and innovative Associate Director, Drug Substance Process Development to be the subject matter expert and leader of RNA manufacturing processes, including upstream and downstream activities.
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The incumbent will be part of the Viral Vector Product Development Leadership Team in defining overall strategy, team growth, budgeting, and providing expertise to project team on all aspects of downstream process development.
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Additional experience in downstream purification of biologics including chromatography separations and filtration operations (depth, dead-end, and ultrafiltration/diafiltration) is a plus.
$200,000 - $240,000 a yearFull-timeExpandApply NowActive JobUpdated 2 days ago - UpvoteDownvoteShare Job
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Lead and mentor scientists/engineers with upstream and downstream processing expertise by fostering an environment for career growth. In addition to its wholly owned clinical assets, Dragonfly has a deep pipeline of wholly owned preclinical candidates discovered using its proprietary platform, as well as productive collaborations with Merck, AbbVie, Gilead and Bristol Myers Squibb in a broad range of disease areas.
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Execute experimental studies to support downstream process development and optimization in several units of operations (clarification, chromatography, and tangential flow filtration) for manufacturing viral vectors.
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In this vital role you will contribute towards Amgen’s Drug Substance Process Development for late stage clinical and commercial biologics programs, including the development, characterization, and scale-up of upstream and downstream manufacturing processes supporting Ph II/III clinical trials to marketing application.
$75,623 - $92,226 a yearExpandUpdated 3 days ago - UpvoteDownvoteShare Job
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Hands-on experience in upstream processes and downstream development and manufacturing of biologics (mAbs, fusion proteins) in a GMP environment. Collaborate with members of upstream and downstream process development teams to optimize early-stage clinical DS processes while leading the technology transfer to commercial CDMOs.
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downstream biologics jobs in Boston, MA
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