{"schemaVersion":"jobsearcher.job.v1","id":"fe53e55e15c93bc11052b9aa","url":"https://jobsearcher.com/jobs/fe53e55e15c93bc11052b9aa","canonicalUrl":"https://jobsearcher.com/jobs/fe53e55e15c93bc11052b9aa","title":"Senior Downstream Process Engineer","description":"Process / Equipment Engineer – Downstream Biologics Startup Location: Holly Springs, NC Schedule: 100% onsite, Monday–Friday Contract: 12+ months, strong extension potentialA growing biopharmaceutical manufacturing organization is seeking Process / Equipment Engineers to support the startup of a large-scale greenfield drug substance manufacturing facility in Holly Springs, NC.These are field-focused roles supporting downstream process equipment installation, commissioning, startup, and early operations. The project is currently in the equipment installation / commissioning phase, with FATs complete and systems being installed onsite.We are hiring across three downstream equipment areas:• Buffer & Product Hold Systems • Chromatography Skids • UF/DF / TFF SystemsWhat You’ll Do: • Serve as system owner for assigned downstream process equipment • Perform P&ID walkdowns and redline discrepancies in the field • Verify installed equipment, piping, and utility tie-ins against design documents • Review equipment installation against P&IDs, piping specs, submittals, and 3D models • Coordinate with vendors, construction teams, CQV, operations, and QA • Support commissioning, startup, deviations, investigations, CAPAs, and risk assessments • Assist with LOTO identification and campaign changeover strategyIdeal Background: • 3–8 years of GMP biopharma engineering experience • Hands-on downstream stainless-steel process equipment experience • Exposure to buffer/product hold tanks, chromatography skids, or UF/DF/TFF systems • Field/startup experience with P&ID walkdowns, redlines, and installation verification • Experience with Navisworks or similar 3D model review tools • BS in Chemical Engineering, Biochemical Engineering, Process Engineering, or related disciplineThis is a strong opportunity for a mid-level engineer who enjoys being in the field, working closely with equipment and systems, and supporting a major biologics facility from installation through startup.Interested candidates can message me directly or send a resume for consideration.","company":"Technical Source","rawCompany":"technical source","city":"Raleigh","state":"NC","isRemote":false,"isActive":false,"createdAt":"2026-05-08T06:45:39.281Z","occupations":[{"code":"17-2041.00","title":"Chemical Engineers","slug":"chemical-engineers"},{"code":"17-2112.03","title":"Manufacturing Engineers","slug":"manufacturing-engineers"},{"code":"17-2031.00","title":"Bioengineers and Biomedical Engineers","slug":"bioengineers-and-biomedical-engineers"}],"industries":[{"code":"541330","title":"Engineering Services","slug":"engineering-services"},{"code":"541714","title":"Research and Development in Biotechnology (except Nanobiotechnology)","slug":"research-and-development-in-biotechnology-except-nanobiotechnology"},{"code":"333248","title":"All Other Industrial Machinery Manufacturing","slug":"all-other-industrial-machinery-manufacturing"}],"jobPosting":{"@context":"https://schema.org","@type":"JobPosting","title":"Senior Downstream Process Engineer","description":"Process / Equipment Engineer – Downstream Biologics Startup Location: Holly Springs, NC Schedule: 100% onsite, Monday–Friday Contract: 12+ months, strong extension potentialA growing biopharmaceutical manufacturing organization is seeking Process / Equipment Engineers to support the startup of a large-scale greenfield drug substance manufacturing facility in Holly Springs, NC.These are field-focused roles supporting downstream process equipment installation, commissioning, startup, and early operations. The project is currently in the equipment installation / commissioning phase, with FATs complete and systems being installed onsite.We are hiring across three downstream equipment areas:• Buffer & Product Hold Systems • Chromatography Skids • UF/DF / TFF SystemsWhat You’ll Do: • Serve as system owner for assigned downstream process equipment • Perform P&ID walkdowns and redline discrepancies in the field • Verify installed equipment, piping, and utility tie-ins against design documents • Review equipment installation against P&IDs, piping specs, submittals, and 3D models • Coordinate with vendors, construction teams, CQV, operations, and QA • Support commissioning, startup, deviations, investigations, CAPAs, and risk assessments • Assist with LOTO identification and campaign changeover strategyIdeal Background: • 3–8 years of GMP biopharma engineering experience • Hands-on downstream stainless-steel process equipment experience • Exposure to buffer/product hold tanks, chromatography skids, or UF/DF/TFF systems • Field/startup experience with P&ID walkdowns, redlines, and installation verification • Experience with Navisworks or similar 3D model review tools • BS in Chemical Engineering, Biochemical Engineering, Process Engineering, or related disciplineThis is a strong opportunity for a mid-level engineer who enjoys being in the field, working closely with equipment and systems, and supporting a major biologics facility from installation through startup.Interested candidates can message me directly or send a resume for consideration.","datePosted":"2026-05-08T06:45:39.281Z","dateModified":"2026-05-08T06:45:39.281Z","hiringOrganization":{"@type":"Organization","name":"Technical Source","sameAs":"https://jobsearcher.com"},"jobLocation":{"@type":"Place","address":{"@type":"PostalAddress","addressLocality":"Raleigh","addressRegion":"NC","addressCountry":"US"}},"identifier":{"@type":"PropertyValue","name":"JobSearcher","value":"fe53e55e15c93bc11052b9aa"},"url":"https://jobsearcher.com/jobs/fe53e55e15c93bc11052b9aa"}}