{"schemaVersion":"jobsearcher.job.v1","id":"d64c584dc031c66678931a44","url":"https://jobsearcher.com/jobs/d64c584dc031c66678931a44","canonicalUrl":"https://jobsearcher.com/jobs/d64c584dc031c66678931a44","title":"Technical Program Manager","description":"Technical Program Manager (open to Senior level) Remote, US Our client is a fast-growing, VC-backed startup building decision infrastructure for drug development. Their platform combines biosimulation, translational science and machine learning to help biopharma teams make better decisions from discovery through development. About the roleThis is not a traditional project management role. You will be the company's first TPM hire, sitting between AI/ML, software engineering, computational science and customer and government programs. You will report to the VP of Technology and work directly with the CEO on the company's most important platform, customer and government programs. You will need to go deep enough technically to understand what the teams are building, spot dependencies and risks, challenge assumptions and drive decisions. You do not need to be the expert in every discipline. What you will do Own complex, cross-functional programs from definition through delivery, resolving blockers rather than just reporting them Turn scientific, product and customer objectives into clear workstreams with owners, milestones, dependencies and budgets Help shape the platform roadmap with technical and scientific leaders, balancing long-term strategy against near-term commercial needs Spot capabilities built for individual programs that should become scalable platform infrastructure Draft SOWs for biopharma and government programs, with scope, deliverables, acceptance criteria and cost estimates built with the technical leads Own program budgets from proposal to delivery, tracking actuals and forecasts against planCatch scope changes early and turn them into updates to timelines, resources, budgets and contractsRun program reviews focused on decisions, risks and budgets rather than status updatesSupport Business Development with clear narratives on the value the company brings to pharma partnersBuild out the TPM function as the company grows What you will bring5+ years in technical program management, technical product management or a similar cross-functional technical leadership role Experience running complex programs where scientists and software, data or ML engineers had to deliver together The ability to understand technical architecture, dependencies and tradeoffs A track record of bringing an at-risk program back on track, and of pushing back on senior leaders when scope or timelines did not hold up Experience building lightweight planning, review and budget tracking processes from scratch Experience developing scopes of work, resource estimates, timelines and budgets Regular use of LLMs and AI tools in your own work, with the judgment to verify outputs and think independently Excellent written and verbal communication Comfort working at pace in a small, fast-changing startupNice to have Background in biotech, biopharma, computational biology, drug discovery or scientific software (optional, not required)Exposure to pharmacology, bioinformatics, toxicology or translational scienceExperience writing SOWs or supporting proposals and contract amendments for pharma, biotech or government customers A degree in computer science, engineering, computational biology or a related quantitative field What is on offer Competitive salary, dependent on location and experienceVery good health insurance A flat, collaborative team with real responsibility, client exposure and room to grow A culture that avoids unnecessary meetings and respects time outside work Working hours and location Fully remote within the USIf you're interested, please apply, and reach out to o.archer@x4lifesciences.com.","company":"X4 Life Sciences","rawCompany":"x4 life sciences","city":"Denver","state":"CO","isRemote":false,"isActive":false,"createdAt":"2026-11-05T07:27:29.218Z","occupations":[{"code":"15-1299.09","title":"Information Technology Project Managers","slug":"information-technology-project-managers"},{"code":"13-1082.00","title":"Project Management Specialists","slug":"project-management-specialists"},{"code":"11-3021.00","title":"Computer and Information Systems Managers","slug":"computer-and-information-systems-managers"}],"industries":[{"code":"541511","title":"Custom Computer Programming Services","slug":"custom-computer-programming-services"},{"code":"541714","title":"Research and Development in Biotechnology (except Nanobiotechnology)","slug":"research-and-development-in-biotechnology-except-nanobiotechnology"},{"code":"325412","title":"Pharmaceutical Preparation Manufacturing","slug":"pharmaceutical-preparation-manufacturing"}],"jobPosting":{"@context":"https://schema.org","@type":"JobPosting","title":"Technical Program Manager","description":"Technical Program Manager (open to Senior level) Remote, US Our client is a fast-growing, VC-backed startup building decision infrastructure for drug development. Their platform combines biosimulation, translational science and machine learning to help biopharma teams make better decisions from discovery through development. About the roleThis is not a traditional project management role. You will be the company's first TPM hire, sitting between AI/ML, software engineering, computational science and customer and government programs. You will report to the VP of Technology and work directly with the CEO on the company's most important platform, customer and government programs. You will need to go deep enough technically to understand what the teams are building, spot dependencies and risks, challenge assumptions and drive decisions. You do not need to be the expert in every discipline. What you will do Own complex, cross-functional programs from definition through delivery, resolving blockers rather than just reporting them Turn scientific, product and customer objectives into clear workstreams with owners, milestones, dependencies and budgets Help shape the platform roadmap with technical and scientific leaders, balancing long-term strategy against near-term commercial needs Spot capabilities built for individual programs that should become scalable platform infrastructure Draft SOWs for biopharma and government programs, with scope, deliverables, acceptance criteria and cost estimates built with the technical leads Own program budgets from proposal to delivery, tracking actuals and forecasts against planCatch scope changes early and turn them into updates to timelines, resources, budgets and contractsRun program reviews focused on decisions, risks and budgets rather than status updatesSupport Business Development with clear narratives on the value the company brings to pharma partnersBuild out the TPM function as the company grows What you will bring5+ years in technical program management, technical product management or a similar cross-functional technical leadership role Experience running complex programs where scientists and software, data or ML engineers had to deliver together The ability to understand technical architecture, dependencies and tradeoffs A track record of bringing an at-risk program back on track, and of pushing back on senior leaders when scope or timelines did not hold up Experience building lightweight planning, review and budget tracking processes from scratch Experience developing scopes of work, resource estimates, timelines and budgets Regular use of LLMs and AI tools in your own work, with the judgment to verify outputs and think independently Excellent written and verbal communication Comfort working at pace in a small, fast-changing startupNice to have Background in biotech, biopharma, computational biology, drug discovery or scientific software (optional, not required)Exposure to pharmacology, bioinformatics, toxicology or translational scienceExperience writing SOWs or supporting proposals and contract amendments for pharma, biotech or government customers A degree in computer science, engineering, computational biology or a related quantitative field What is on offer Competitive salary, dependent on location and experienceVery good health insurance A flat, collaborative team with real responsibility, client exposure and room to grow A culture that avoids unnecessary meetings and respects time outside work Working hours and location Fully remote within the USIf you're interested, please apply, and reach out to o.archer@x4lifesciences.com.","datePosted":"2026-11-05T07:27:29.218Z","dateModified":"2026-11-05T07:27:29.218Z","hiringOrganization":{"@type":"Organization","name":"X4 Life Sciences","sameAs":"https://jobsearcher.com"},"jobLocation":{"@type":"Place","address":{"@type":"PostalAddress","addressLocality":"Denver","addressRegion":"CO","addressCountry":"US"}},"identifier":{"@type":"PropertyValue","name":"JobSearcher","value":"d64c584dc031c66678931a44"},"url":"https://jobsearcher.com/jobs/d64c584dc031c66678931a44"}}