{"schemaVersion":"jobsearcher.job.v1","id":"d2a711d35f88e4bafe79be8f","url":"https://jobsearcher.com/jobs/d2a711d35f88e4bafe79be8f","canonicalUrl":"https://jobsearcher.com/jobs/d2a711d35f88e4bafe79be8f","title":"Senior Application Security Engineer","description":"Passionate about precision medicine and advancing the healthcare industry?\nRecent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.\nTempus is seeking a Senior Application Security Engineer with deep expertise in penetration testing to lead efforts in identifying and remediating vulnerabilities across web, mobile, and medical device applications. You will safeguard sensitive healthcare data and ensure the security of our internal systems and software medical device (SaMD) products, supporting our mission to improve patient outcomes through secure-by-design principles.\nKey Responsibilities\nExecute advanced black-box and grey-box penetration tests on web applications, APIs (REST/GraphQL), and internal systems.\nPerform deep-dive mobile security assessments on iOS and Android, including reverse engineering and bypassing client-side controls like root detection and certificate pinning.\nLead specialized security testing and threat modeling for FDA-regulated medical device software, ensuring compliance with HIPAA, GDPR, and FDA cybersecurity guidelines.\nDevelop high-quality technical reports detailing exploit chains and business logic flaws, providing engineering teams with hands-on remediation guidance.\nAutomate security testing by developing custom tools and scripts in languages such as Python, Go, or PowerShell.\nCommunicate complex security risks and business impacts to executive leadership and cross-functional stakeholders.\nMentor junior team members and provide security training to development teams to foster a robust culture of security awareness.\nQualifications\n5+ years of experience in penetration testing, ideally within healthcare or highly regulated environments.\nExpert knowledge of web/API vulnerabilities (OWASP Top 10) and mobile testing frameworks (Frida, Burp Suite, MobSF, Ghidra).\nUnderstanding of medical protocols (DICOM, HL7) and cloud security practices (AWS, Azure, or GCP).\nProficiency in scripting languages (Python, JavaScript/TypeScript, Go) and secure SDLC practices.\nExcellent analytical, problem-solving, and interpersonal communication skills.\nPreferred Certifications\nOffensive Security: OSCP, OSCE, or OSWE.\nMobile Security: eCMAP or GMOB.\nGeneral/Regulated: CEH, CSSLP, GPEN, GWAPT, or UL 2900 training.\nCHI: $130,000-$180,000\nThe expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.\nWe are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.\n\nAbout Us\nTempus was founded in August of 2015 by Eric Lefkofsky, after his wife was diagnosed with Breast Cancer. Shortly after he founded the company in an effort to bring the power of technology and artificial intelligence to cancer care, he convinced Ryan Fukushima to join as the company’s first employee. Ryan and Eric began assembling a world class team, focused on building the first version of a platform capable of ingesting real time healthcare data in an effort to personalize diagnostics.\nWe built the platform for oncology and have expanded it to neuropsychiatry, cardiology, infectious disease (through COVID), and radiology. Despite our rapid growth, our mission remains the same—to help make sure patients are on the right drug at the right time, so they can live longer and healthier lives.\n\nWhy Work Here?\n\nWe’re looking for people who can change the world.\n\nWho question the status quo and don’t shy away from tough problems. For the builders who are never done building and the learners who are never done learning. We’re looking for passionate people with undying curiosity. Those who want to attack one of the most challenging problems mankind has ever faced. Head on.","company":"Tempus","rawCompany":"tempus","city":"Chicago","state":"IL","isRemote":false,"isActive":true,"createdAt":"2026-08-06T13:26:03.355Z","occupations":[{"code":"15-1299.05","title":"Information Security Engineers","slug":"information-security-engineers"},{"code":"15-1299.04","title":"Penetration Testers","slug":"penetration-testers"},{"code":"15-1212.00","title":"Information Security Analysts","slug":"information-security-analysts"}],"industries":[{"code":"541512","title":"Computer Systems Design Services","slug":"computer-systems-design-services"},{"code":"541511","title":"Custom Computer Programming Services","slug":"custom-computer-programming-services"},{"code":"541690","title":"Other Scientific and Technical Consulting Services","slug":"other-scientific-and-technical-consulting-services"}],"jobPosting":{"@context":"https://schema.org","@type":"JobPosting","title":"Senior Application Security Engineer","description":"Passionate about precision medicine and advancing the healthcare industry?\nRecent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.\nTempus is seeking a Senior Application Security Engineer with deep expertise in penetration testing to lead efforts in identifying and remediating vulnerabilities across web, mobile, and medical device applications. You will safeguard sensitive healthcare data and ensure the security of our internal systems and software medical device (SaMD) products, supporting our mission to improve patient outcomes through secure-by-design principles.\nKey Responsibilities\nExecute advanced black-box and grey-box penetration tests on web applications, APIs (REST/GraphQL), and internal systems.\nPerform deep-dive mobile security assessments on iOS and Android, including reverse engineering and bypassing client-side controls like root detection and certificate pinning.\nLead specialized security testing and threat modeling for FDA-regulated medical device software, ensuring compliance with HIPAA, GDPR, and FDA cybersecurity guidelines.\nDevelop high-quality technical reports detailing exploit chains and business logic flaws, providing engineering teams with hands-on remediation guidance.\nAutomate security testing by developing custom tools and scripts in languages such as Python, Go, or PowerShell.\nCommunicate complex security risks and business impacts to executive leadership and cross-functional stakeholders.\nMentor junior team members and provide security training to development teams to foster a robust culture of security awareness.\nQualifications\n5+ years of experience in penetration testing, ideally within healthcare or highly regulated environments.\nExpert knowledge of web/API vulnerabilities (OWASP Top 10) and mobile testing frameworks (Frida, Burp Suite, MobSF, Ghidra).\nUnderstanding of medical protocols (DICOM, HL7) and cloud security practices (AWS, Azure, or GCP).\nProficiency in scripting languages (Python, JavaScript/TypeScript, Go) and secure SDLC practices.\nExcellent analytical, problem-solving, and interpersonal communication skills.\nPreferred Certifications\nOffensive Security: OSCP, OSCE, or OSWE.\nMobile Security: eCMAP or GMOB.\nGeneral/Regulated: CEH, CSSLP, GPEN, GWAPT, or UL 2900 training.\nCHI: $130,000-$180,000\nThe expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.\nWe are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.\n\nAbout Us\nTempus was founded in August of 2015 by Eric Lefkofsky, after his wife was diagnosed with Breast Cancer. Shortly after he founded the company in an effort to bring the power of technology and artificial intelligence to cancer care, he convinced Ryan Fukushima to join as the company’s first employee. Ryan and Eric began assembling a world class team, focused on building the first version of a platform capable of ingesting real time healthcare data in an effort to personalize diagnostics.\nWe built the platform for oncology and have expanded it to neuropsychiatry, cardiology, infectious disease (through COVID), and radiology. Despite our rapid growth, our mission remains the same—to help make sure patients are on the right drug at the right time, so they can live longer and healthier lives.\n\nWhy Work Here?\n\nWe’re looking for people who can change the world.\n\nWho question the status quo and don’t shy away from tough problems. For the builders who are never done building and the learners who are never done learning. We’re looking for passionate people with undying curiosity. Those who want to attack one of the most challenging problems mankind has ever faced. Head on.","datePosted":"2026-08-06T13:26:03.355Z","dateModified":"2026-08-06T13:26:03.355Z","hiringOrganization":{"@type":"Organization","name":"Tempus","sameAs":"https://jobsearcher.com"},"jobLocation":{"@type":"Place","address":{"@type":"PostalAddress","addressLocality":"Chicago","addressRegion":"IL","addressCountry":"US"}},"identifier":{"@type":"PropertyValue","name":"JobSearcher","value":"d2a711d35f88e4bafe79be8f"},"url":"https://jobsearcher.com/jobs/d2a711d35f88e4bafe79be8f"}}