Analytical Science and Technology Senior Scientist

Job DescriptionGeneral Summary:Vertex is seeking a highly motivated and experienced Senior Scientist to join the Analytical Science and Technology team. In this role, you will work closely with contract manufacturing organizations and a diverse, cross-functional group of scientists at Vertex to solve complex challenges encountered during late-stage development and commercial manufacturing of small-molecule drug products.The ideal candidate will have a strong scientific foundation and a proven track record of developing, implementing, and troubleshooting analytical methods within the pharmaceutical industry. This individual should thrive in a fast-paced environment and demonstrate the ability to collaborate effectively across cross-functional teams, communicate clearly, and drive solutions to support product development and commercial success.Key Duties And ResponsibilitiesDesigns and performs elaborate and technically challenging analytical experiments in compliance with applicable regulations and SOPsLead analytical method transfer activities for small molecule drug product to CMOs or between internal groupsSupport method validation or co-validation activities for late-phase development and commercial programsPrepare, review, and approve technical documentation for commercial products, including analytical methods, SOPs, transfer protocols and reports, laboratory records, and technical reports.Serve as the primary analytical lead for external CMOs, overseeing analytical service execution, driving investigations, and partnering on process-related issue resolutionAnalyze and trend commercial data to support continued process verification, identify emerging issues, and inform data-driven decisions.Support product lifecycle management activities and implement continuous process improvement through commercial change control Knowledge And SkillsStrong practical analytical chemistry skills across a range of general analytical techniques that must include (U)HPLC and GCProven experience in analytical development or technical operations, supporting late-stage development, commercialization and post-approval activitiesDemonstrated expertise in problem-solving and root cause analysis for analytical related issuesStrong technical knowledge of chromatographic methods, including HPLC, GC, and other analytical techniques commonly used in pharmaceutical analysisExperience applying compendial methods such as KF, elemental impurity testing, spectroscopic identification)Solid understanding of cGMP regulations, ICH guidelines and CMC regulatory expectations in a pharmaceutical settingProficiency in data analysis, trending and visualization tools to support decision-making and process monitoringStrong communication, collaboration and technical writing skillsProven ability to work successfully in a fast-paced, matrixed environment while also operating independently with minimal supervisionStrong project management skills and the flexibility to adjust to shifting project priorities and business needsEducation And ExperienceBachelor's, Master's, or PhD in Chemistry, Chemical Engineering, Pharmaceutical Chemistry or other natural scienceTypically requires the following, or the equivalent combination of education and experience: PhD and 3+ years, or Master's and 5+ years, or Bachelor's and 8+ years.Pay Range$122,400 - $183,600Disclosure StatementThe range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.Flex DesignationHybrid-Eligible Or On-Site EligibleFlex Eligibility StatusIn this Hybrid-Eligible role, you can choose to be designated as: Hybrid: work remotely up to two days per week; or select On-Site: work five days per week on-site with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.Company InformationVertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com