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The Scientist I, In Vitro Pharmacology will play a key role in the pre-clinical pharmacology and toxicology team conducting in vitro studies to support in vivo tLNP-CAR product candidate testing, optimization and development for various indications including autoimmunity, fibrosis or oncology.
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Background in lab animal (in vivo) research is a must. This position requires a broad knowledge of animal anatomy, physiology, and surgery to help develop and support in vivo models to screen therapeutics and devices being developed for various indications.
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Calibr-Skaggs supplements the discovery process with the required disciplines for drug development which include chemical library screening, medicinal chemistry, in-vivo model optimization, formulation development, pharmacokinetic and toxicologic expertise, and early clinical development.
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Oversees the development and validation of quantitative in vivo assays to enable PK/PD characterization of therapeutic antibodies. PhD, PharmD or equivalent in Pharmacokinetics, Pharmacology, Bioanalytical or related field with at least 5+ years of experience in Clinical Pharmacology, DMPK or related disciplines required.
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This position is a key member of the development team, executing clinical drug development activities by evaluating the clinical pharmacology of antibody therapeutics in an excellent organization that focused primarily, but not exclusively, on immune-inflammatory diseases.
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Ph. D. in a scientific discipline (e.g., molecular biology, cell biology, or related field) with 0-2 plus years of hands-on experience with gene editing, site-specific nucleases (especially RNguided nucleases), transposons, or other vectors used in vivo or in vitro, is required.
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The ideal candidate will have direct experience in managing and executing in vivo experiments in rodent species from study design through reporting. Muscle contraction studies including chemo-mechanical transduction mechanisms as well as whole and skinned ex vivo muscle fiber studiesPrior evidence of successful contributions working in a team-based interdisciplinary environmentA multi-tasker and problem solver with strong verbal and written communication skills as well as a team-first mindset.
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Support the development of assays to measure the in vitro and in vivo interaction of biopharmaceutical drugs with their cellular targets. Design and execute bioanalytical experiments in support of preclinical studies and clinical programs in a fast-paced, highly interactive environment.
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We use state-of-the-art in vivo functional imaging, electrophysiological recordings, mouse genetics, neuronal activity manipulation, animal behavior, and computational approaches (Ran et al., Nature, 2022.
$20.07 - $25.06 an hourFull-timeExpandApply NowActive JobUpdated Yesterday - UpvoteDownvoteShare Job
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The company focuses on of the development of next generation antibody drugs, developing a protein engineering platform capable of in vivo characterization of proteins at a scale one-thousand times greater than state-of-the-art.
$160,000 - $200,000 a yearFull-timeExpandApply NowActive JobUpdated 3 days ago - UpvoteDownvoteShare Job
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Under supervision, the Clinical Research Coordinator Ast. will be assigned to coordinate multiple federally-funded and industry-sponsored research studies involving human subjects that are being conducted in the UCSD Cardiovascular Institute and at other local locations.
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The in vivo gene editing team is dedicated to constantly improve and evaluate our Cas-CLOVER™ and Super piggyBac® platforms for in vivo applications. Master's or Bachelor's degree in molecular biology, cell biology, virology or related scientific discipline with at least 2 years relevant experience (an equivalent combination of education and experience may be considered.
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The Cedars-Sinai Infectious and Immunological Diseases Research Center (IIDRC) Department of Biomedical Sciences and the Pediatrics Department (Arditi Lab) are seeking a highly motivated Postdoctoral Research Scientist, for NIH-funded cardiovascular immunobiology and mitochondrial biology research.
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HD Biosciences, Inc. (US), a WuXi AppTec Company, is seeking a highly motivated and established Executive Director with deep and broad expertise in in vitro pharmacology including assay development, HTS/SAR, and compound management to join us.
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Operates and maintains water/wastewater treatment, processing, disposal and testing equipment in water/wastewater treatment facility to purify water to meet permit and operational requirements.
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nih in vivo jobs Title: post doctoral fellow Company: Emory University in San Diego, CA
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