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Characterization and purification of novel oligonucleotides using HPLC and LCMS. We are looking for candidates as Research Associate I or II, Oligonucleotide Chemistry to join our discovery chemistry team to advance cutting-edge RNA editing drug discovery programs.
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Excellent proficiency in molecular biological techniques including DNA purification, molecular cloning, protein purification. Calibr-Skaggs supplements the discovery process with the required disciplines for drug development which include chemical library screening, medicinal chemistry, in-vivo model optimization, formulation development, pharmacokinetic and toxicologic expertise, and early clinical development.
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Experience with protein purification using an AKTA system and protein characterization using HPLC (analytical SEC), SDS-PAGE, and mass spectrometry. Experience with protein purification using an AKTA system and protein characterization using HPLC (analytical SEC), SDS-PAGE, and mass spectrometry.
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Knowledge of methods for protein purification, conjugation to fluorochrome and haptens, flow cytometry, immunochemical and immunoassay techniques highly desirable. Knowledge of methods for protein purification, conjugation to fluorochrome and haptens, flow cytometry, immunochemical and immunoassay techniques highly desirable.
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Responsibilities include general lab support such as basic biochemical analyses; protein purification, plasmid construction, tissue culture, gel preparation and Western blot analysis. Responsibilities include general lab support such as basic biochemical analyses; protein purification, plasmid construction, tissue culture, gel preparation and Western blot analysis.
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Performs purification and analysis of samples for upstream process development activities, including but not limit to POROS titer assay and spent media amino acid analysis. Experience with protein purification, characterization, and analytical methods.
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Experience in various cell and molecular biology techniques including, cell culture (primary and stable cell lines), transfection, stable cell line generation, MSD, ELISA, RNA purification, RT-qPCR, western blots, and other standard cell-based or biochemical assays.
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Proficient in all aspects of modern peptide synthesis, protein bioconjugation, peptide and protein purification and analysis. Design, synthesize and characterize peptides, small proteins and chemically-modified analogs using state-of-the-art synthesis, bioconjugation, purification, analytical and biophysical techniques.
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Growth and maintenance, principally of the specified US Territory through direct sales/after-sales support of purification products and services to our customers within the biopharmaceutical sector.
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Proficient in all aspects of modern peptide synthesis, bioconjugation, purification and analysis; capable of immediate independent laboratory work on solid- and solution-phase chemistry. Proficient in all aspects of modern peptide synthesis, bioconjugation, purification and analysis; capable of immediate independent laboratory work on solid- and solution-phase chemistry.
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Research Associate I-II, Discovery Chemistry – Oligonucleotide (Purification) Research Associate I-II, Discovery Chemistry – Oligonucleotide (Purification) We are seeking a highly motivated and qualified individual to join our Discovery Chemistry-Oligonucleotide Team as a Research Associate I-II and work as part of a team to drive success.
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Knowledge and experimental ability to perform procedures used in a molecular biology research laboratory setting such as sterile technique, DNA and RNA preparation, protein purification, PCR amplification, bacterial transformation, western blotting, cloning, bacterial growth and handling, plasmid preparation.
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The focus of the role will be optimizing in-vitro transcription reactions and downstream purification processes for mRNA production. Strategize and execute the deployment of scalable mRNA purification methodologies, incorporating advanced chromatography and tangential flow filtration techniques.
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Experience with T-cell characterization methods (flow cytometry (multiparametric and ICS), cell-based assays (proliferation, cytotoxicity), ELISA, multiplex cytokine assays,purification using MACS system, etc.
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The Research Associate will be responsible for conducting hands-on experiments including but not limited to molecular biology, mammalian cell culture, recombinant protein purification and characterization.
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purification job Company: Genomatica in Bonita, CA
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