{"schemaVersion":"jobsearcher.job.v1","id":"aefc90a185e4a8aade1c7b7f","url":"https://jobsearcher.com/jobs/aefc90a185e4a8aade1c7b7f","canonicalUrl":"https://jobsearcher.com/jobs/aefc90a185e4a8aade1c7b7f","title":"Manager, Development Sciences Operations","description":"Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.\nWe invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.\nThe company is seeking an experienced and highly motivated Development Sciences Operations Manager responsible for oversight of technical and operational aspects of Development Sciences workflows, including those conducted at external CRO laboratories in support of Toxicology, Pathology, Biomarker, Bioanalytical, and DMPK/Clinical Pharmacology functions. This individual will work in close collaboration with colleagues in Discovery Research and Development Sciences and will be responsible for working with members of cross-functional teams to liaise with Contract Research Organizations (CROs), monitor studies, manage vendor relationships and contracts, and potentially contribute to the design, execution, and reporting of nonclinical studies for Denali Therapeutics products.\nKey Accountabilities/Core Job Responsibilities :\nServe as Safety Assessment (Toxicology/Pathology), DMPK, Clinical Pharmacology, Biomarker, and Bioanalytical function interface between Denali and external CRO collaborators, developing productive relationships to achieve optimal efficiency in external workflows in GLP, GCP and GCLP areas.\nManage identification (RFI), partnering with Legal and Contracts group in managing the operational aspects of pre-clinical contracts and change orders, including active negotiation of scope of work, payment terms and budgets.\nManage study operational logistics, including establishing timelines for deliverables, facilitate test material logistics, and support the trafficking of samples, data, and documents\nProvide support in implementing, managing, and monitoring outsourced nonclinical Toxicology studies (non-GLP and GLP) to support all phases of drug development\nRemote and onsite oversight of nonclinical studies to ensure studies are conducted to the highest standards\nResponsible for working with DMPK scientists to identify CRO laboratories capable of conduct of in vitro and in vivo experiments supporting candidate identification and IND-enabling efforts.\nEngage CROs and internal scientists to outline protocols/SOWs.\nReceive and review study results and summary reports, ensuring data and reports are integrated into internal databases; help design tools to aid in data upload, migration, and visualization.\nEnsure compliance with study protocols, IACUC regulations, and SOPs.\n\nQualifications/Skills :\nBS/MS in Toxicology, Pharmacology, Biological Sciences or related discipline with 3+ years of biopharmaceutical industry experience.\nExperience working with nonclinical CROs, developing protocols, and an understanding of technical and organizational aspects of study conduct, including knowledge of current animal welfare philosophies and 3Rs.\nAbility to perform data entry into data warehouses (e.g., Dotmatics/Benchling) and manage data visualization software (Tableau, SEND explorer).\nOutstanding organization and planning skills, and the ability to assess risks and manage external workflows to meet project team deliverables.\nExcellent analytical, critical thinking, and soft skills to build collaborative relationships enabling effective professional interactions with vendors and stakeholders.\nProven ability to thrive in a collaborative team environment: strong oral and written communication skills, and a helpful team spirit.\nSalary Range: $160,000.00 to $202,000.00 .  Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers\nThis compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.\nÂ\nDenali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.","company":"Denalitherapeutics","rawCompany":"denalitherapeutics","city":"Millbrae","state":"CA","isRemote":false,"isActive":false,"createdAt":"2026-04-14T11:09:07.027Z","occupations":[{"code":"11-9121.00","title":"Natural Sciences Managers","slug":"natural-sciences-managers"},{"code":"19-1042.00","title":"Medical Scientists, Except Epidemiologists","slug":"medical-scientists-except-epidemiologists"},{"code":"11-1021.00","title":"General and Operations Managers","slug":"general-and-operations-managers"}],"industries":[{"code":"541714","title":"Research and Development in Biotechnology (except Nanobiotechnology)","slug":"research-and-development-in-biotechnology-except-nanobiotechnology"},{"code":"325412","title":"Pharmaceutical Preparation Manufacturing","slug":"pharmaceutical-preparation-manufacturing"},{"code":"541715","title":"Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)","slug":"research-and-development-in-the-physical-engineering-and-life-sciences-except-nanotechnology-and-biotechnology"}],"jobPosting":{"@context":"https://schema.org","@type":"JobPosting","title":"Manager, Development Sciences Operations","description":"Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.\nWe invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.\nThe company is seeking an experienced and highly motivated Development Sciences Operations Manager responsible for oversight of technical and operational aspects of Development Sciences workflows, including those conducted at external CRO laboratories in support of Toxicology, Pathology, Biomarker, Bioanalytical, and DMPK/Clinical Pharmacology functions. This individual will work in close collaboration with colleagues in Discovery Research and Development Sciences and will be responsible for working with members of cross-functional teams to liaise with Contract Research Organizations (CROs), monitor studies, manage vendor relationships and contracts, and potentially contribute to the design, execution, and reporting of nonclinical studies for Denali Therapeutics products.\nKey Accountabilities/Core Job Responsibilities :\nServe as Safety Assessment (Toxicology/Pathology), DMPK, Clinical Pharmacology, Biomarker, and Bioanalytical function interface between Denali and external CRO collaborators, developing productive relationships to achieve optimal efficiency in external workflows in GLP, GCP and GCLP areas.\nManage identification (RFI), partnering with Legal and Contracts group in managing the operational aspects of pre-clinical contracts and change orders, including active negotiation of scope of work, payment terms and budgets.\nManage study operational logistics, including establishing timelines for deliverables, facilitate test material logistics, and support the trafficking of samples, data, and documents\nProvide support in implementing, managing, and monitoring outsourced nonclinical Toxicology studies (non-GLP and GLP) to support all phases of drug development\nRemote and onsite oversight of nonclinical studies to ensure studies are conducted to the highest standards\nResponsible for working with DMPK scientists to identify CRO laboratories capable of conduct of in vitro and in vivo experiments supporting candidate identification and IND-enabling efforts.\nEngage CROs and internal scientists to outline protocols/SOWs.\nReceive and review study results and summary reports, ensuring data and reports are integrated into internal databases; help design tools to aid in data upload, migration, and visualization.\nEnsure compliance with study protocols, IACUC regulations, and SOPs.\n\nQualifications/Skills :\nBS/MS in Toxicology, Pharmacology, Biological Sciences or related discipline with 3+ years of biopharmaceutical industry experience.\nExperience working with nonclinical CROs, developing protocols, and an understanding of technical and organizational aspects of study conduct, including knowledge of current animal welfare philosophies and 3Rs.\nAbility to perform data entry into data warehouses (e.g., Dotmatics/Benchling) and manage data visualization software (Tableau, SEND explorer).\nOutstanding organization and planning skills, and the ability to assess risks and manage external workflows to meet project team deliverables.\nExcellent analytical, critical thinking, and soft skills to build collaborative relationships enabling effective professional interactions with vendors and stakeholders.\nProven ability to thrive in a collaborative team environment: strong oral and written communication skills, and a helpful team spirit.\nSalary Range: $160,000.00 to $202,000.00 .  Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers\nThis compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.\nÂ\nDenali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.","datePosted":"2026-04-14T11:09:07.027Z","dateModified":"2026-04-14T11:09:07.027Z","hiringOrganization":{"@type":"Organization","name":"Denalitherapeutics","sameAs":"https://jobsearcher.com"},"jobLocation":{"@type":"Place","address":{"@type":"PostalAddress","addressLocality":"Millbrae","addressRegion":"CA","addressCountry":"US"}},"identifier":{"@type":"PropertyValue","name":"JobSearcher","value":"aefc90a185e4a8aade1c7b7f"},"url":"https://jobsearcher.com/jobs/aefc90a185e4a8aade1c7b7f"}}