Senior Research Associate, PK/PD Assays
About NewLimitNewLimit is seeking a Senior Research Associate with strong experience in molecular biology and translational biomarker assay development to join our team. This role will contribute to the development and execution of pharmacokinetic (PK) and pharmacodynamic (PD) assays to support our therapeutic programs. You will work closely with cross-functional teams to develop and implement molecular assays that quantify the biodistribution of our mRNA-LNP medicines and the biological response to them in preclinical studies.What You'll DoDevelop, validate, and execute PK and PD biomarker assays to support preclinical studies and therapeutic discovery programsDesign and perform molecular biology assays (e.g., qPCR, RT-qPCR, ddPCR, NGS-based assays, ELISA) to quantify nucleic acids, gene and protein expression in biological samplesContribute to experimental sample processing and preparation workflows including animal dissections, tissue harvesting, and primary cell cultureCollaborate with our Epigenetic Editing team to perform large-scale, single-cell perturbation experimentsPerform state-of-the-art single-cell profiling experiments to map epigenetic features of agingRequirementsBachelor's degree in molecular biology, cell biology, biochemistry, or a related scientific field2+ years of laboratory experience in molecular biology and quantitative assay development (e.g., qPCR, RT-qPCR, ddPCR, ELISA, NGS-based)Hands-on experience with primary cell culture, tissue harvesting and complex biological matrices for molecular assaysFamiliarity with bioanalytical assay qualification/validation principles for PK/PD biomarker measurementsUnderstanding of data quality, documentation, and experimental practices aligned with preclinical regulatory expectations (e.g., GLP-like practices or bioanalytical method validation guidelines)Nice to haveExperience working in environments following GLP or regulated bioanalytical workflows supporting preclinical or IND-enabling studiesExperience with flow cytometry sortingExperience with NGS methodsBenefitsComprehensive Health, Dental, and Vision insurance401(k) plan with company matchPaid parental leaveIndustry-leading PTO: 20 days per year plus holidaysOn-site meals and snacksSalary Range: $90,000 to $110,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.J-18808-Ljbffr