{"schemaVersion":"jobsearcher.job.v1","id":"700a703683e04fcc51cb673d","url":"https://jobsearcher.com/jobs/700a703683e04fcc51cb673d","canonicalUrl":"https://jobsearcher.com/jobs/700a703683e04fcc51cb673d","title":"Manager, Statistical Programming","description":"Overview\nIn this role you will provide hands-on statistical programming support for clinical studies, regulatory submissions, and cross-functional development. You will deliver analysis datasets, tables, listings, and figures, and contribute to study-level and integrated submission deliverables while partnering with Biostatistics, Data Management, Clinical Development, Medical Writing, Regulatory, and external vendors. Depending on level, you may oversee processes, mentor programmers, and drive standards and vendor oversight. This is a hybrid, Boston-based opportunity contributing to Rhythm’s mission to transform care for patients with rare neuroendocrine diseases.\n\nCompensation / Benefitshybrid-work modeldiscretionary annual bonusbenefits packagerestricted stock units (RSUs)salary range $110,000 - $165,000opportunity for career growth\nResponsibilitiesLead or support programming activities for clinical studies, including development, validation, and QC of ADaM datasets, TLFs, and figures for reports and submissionsServe as study lead programmer or representative, coordinating with cross-functional teams and external vendors to ensure timely, high-quality resultsDevelop and maintain ADaM specifications, TLF shells, programming docs, reusable macros, and study-level standards in line with procedures and regulatory expectationsContribute to study protocols, SAPs, CRF design/annotation, edit checks, SDTM specs, and submission strategy to ensure traceability and efficient downstream analysisSupport regulatory submission readiness, including prepare/review define.xml, reviewer guides, and submission-ready datasets per CDISC and global requirementsIdentify programming risks, drive issue resolution, and propose process improvements to enhance quality, scalability, and inspection readinessMentor junior programmers (where applicable), oversee vendor deliverables, and contribute to resource planning and departmental standardsWork autonomously in a fast-paced environment, collaborating across functions to deliver high-quality analyses and submissions\nKey requirementsMS or equivalent degree in Statistics, Biostatistics, Mathematics, Computer Science, or related discipline; advanced degree preferred3-5 years of relevant statistical programming experience in biotech, pharma, or CRO settingsStrong hands-on SAS programming expertise (Base SAS, SAS/STAT, SAS/GRAPH, SAS/SQL, SAS/ODS) and macro development; experience with R is a plusDeep knowledge of CDISC standards (SDTM, ADaM, define.xml) and electronic submission requirements (eCTD)Experience supporting study-level and integrated analyses (ISS/ISE) and regulatory submission processesAbility to work independently, manage priorities, collaborate cross-functionally, and deliver high-quality work in a fast-paced environmentFor manager-level candidates, mentoring programmers, overseeing external vendors, and contributing to resource planning is a plusLocation: Boston, MA; willingness to hybrid-work and travel as neededCollaborative mindsetStrong problem-solving and organizational skillsAdaptability and willingness to learnSAS programming (Base, STAT, GRAPH, SQL, ODS)Macro developmentR (plus)","company":"Rhythm Pharmaceuticals","rawCompany":"rhythm pharmaceuticals","city":"Quincy","state":"MA","isRemote":false,"isActive":false,"createdAt":"2026-09-15T04:28:59.348Z","occupations":[{"code":"15-2041.01","title":"Biostatisticians","slug":"biostatisticians"},{"code":"15-2041.00","title":"Statisticians","slug":"statisticians"},{"code":"11-9121.00","title":"Natural Sciences Managers","slug":"natural-sciences-managers"}],"industries":[{"code":"541714","title":"Research and Development in Biotechnology (except Nanobiotechnology)","slug":"research-and-development-in-biotechnology-except-nanobiotechnology"},{"code":"541715","title":"Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)","slug":"research-and-development-in-the-physical-engineering-and-life-sciences-except-nanotechnology-and-biotechnology"},{"code":"541690","title":"Other Scientific and Technical Consulting Services","slug":"other-scientific-and-technical-consulting-services"}],"jobPosting":{"@context":"https://schema.org","@type":"JobPosting","title":"Manager, Statistical Programming","description":"Overview\nIn this role you will provide hands-on statistical programming support for clinical studies, regulatory submissions, and cross-functional development. You will deliver analysis datasets, tables, listings, and figures, and contribute to study-level and integrated submission deliverables while partnering with Biostatistics, Data Management, Clinical Development, Medical Writing, Regulatory, and external vendors. Depending on level, you may oversee processes, mentor programmers, and drive standards and vendor oversight. This is a hybrid, Boston-based opportunity contributing to Rhythm’s mission to transform care for patients with rare neuroendocrine diseases.\n\nCompensation / Benefitshybrid-work modeldiscretionary annual bonusbenefits packagerestricted stock units (RSUs)salary range $110,000 - $165,000opportunity for career growth\nResponsibilitiesLead or support programming activities for clinical studies, including development, validation, and QC of ADaM datasets, TLFs, and figures for reports and submissionsServe as study lead programmer or representative, coordinating with cross-functional teams and external vendors to ensure timely, high-quality resultsDevelop and maintain ADaM specifications, TLF shells, programming docs, reusable macros, and study-level standards in line with procedures and regulatory expectationsContribute to study protocols, SAPs, CRF design/annotation, edit checks, SDTM specs, and submission strategy to ensure traceability and efficient downstream analysisSupport regulatory submission readiness, including prepare/review define.xml, reviewer guides, and submission-ready datasets per CDISC and global requirementsIdentify programming risks, drive issue resolution, and propose process improvements to enhance quality, scalability, and inspection readinessMentor junior programmers (where applicable), oversee vendor deliverables, and contribute to resource planning and departmental standardsWork autonomously in a fast-paced environment, collaborating across functions to deliver high-quality analyses and submissions\nKey requirementsMS or equivalent degree in Statistics, Biostatistics, Mathematics, Computer Science, or related discipline; advanced degree preferred3-5 years of relevant statistical programming experience in biotech, pharma, or CRO settingsStrong hands-on SAS programming expertise (Base SAS, SAS/STAT, SAS/GRAPH, SAS/SQL, SAS/ODS) and macro development; experience with R is a plusDeep knowledge of CDISC standards (SDTM, ADaM, define.xml) and electronic submission requirements (eCTD)Experience supporting study-level and integrated analyses (ISS/ISE) and regulatory submission processesAbility to work independently, manage priorities, collaborate cross-functionally, and deliver high-quality work in a fast-paced environmentFor manager-level candidates, mentoring programmers, overseeing external vendors, and contributing to resource planning is a plusLocation: Boston, MA; willingness to hybrid-work and travel as neededCollaborative mindsetStrong problem-solving and organizational skillsAdaptability and willingness to learnSAS programming (Base, STAT, GRAPH, SQL, ODS)Macro developmentR (plus)","datePosted":"2026-09-15T04:28:59.348Z","dateModified":"2026-09-15T04:28:59.348Z","hiringOrganization":{"@type":"Organization","name":"Rhythm Pharmaceuticals","sameAs":"https://jobsearcher.com"},"jobLocation":{"@type":"Place","address":{"@type":"PostalAddress","addressLocality":"Quincy","addressRegion":"MA","addressCountry":"US"}},"identifier":{"@type":"PropertyValue","name":"JobSearcher","value":"700a703683e04fcc51cb673d"},"url":"https://jobsearcher.com/jobs/700a703683e04fcc51cb673d"}}