{"schemaVersion":"jobsearcher.job.v1","id":"6805c883f6caa129308a372b","url":"https://jobsearcher.com/jobs/6805c883f6caa129308a372b","canonicalUrl":"https://jobsearcher.com/jobs/6805c883f6caa129308a372b","title":"Senior Microscope Engineer","description":"About us\nEon is building the infrastructure for large-scale connectomics data collection, reconstruction, and brain simulation. Our mission is to enable the safe and scalable development of brain emulation technology, beginning with digital twins of model organisms.\nWe are developing an end-to-end platform that spans tissue preparation, high-throughput microscopy, large-scale image processing, neural reconstruction, connectome-based modeling, and embodied simulation. We are looking for exceptional engineers and scientists who can help turn biological brain data into usable computational systems.\nRole\nWe are seeking a Senior Microscope Engineer to build and scale the imaging systems at the heart of our connectomics pipeline. You will design, build, and bring up custom high-throughput optical microscopes optimized for imaging expanded brain tissue, take our current prototype through to a production-ready instrument, and lead its replication into a small fleet for large-scale acquisition.\nThis is a hands-on role for someone who has personally built high-throughput microscopes end to end — optics, optomechanics, illumination, detection, and control — and who is comfortable moving between instrument design, day-to-day acquisition, and the practical problem-solving that scaling a novel imaging system demands.\nResponsibilities\nDesign and build custom, cost-effective, high-throughput optical microscopes (e.g., spinning-disk confocal) optimized for expanded tissue.\nTake a working prototype to a production-ready instrument: motorized staging, optimized acquisition, and validated performance.\nOperate microscopes to acquire high-resolution 3D image volumes of expanded neural tissue, sustaining high throughput and high instrument uptime.\nProduce complete build documentation — bills of materials, budgets, timelines, and assembly SOPs a technician can follow — and lead replication toward a small fleet.\nTroubleshoot imaging issues and perform routine maintenance on microscopy equipment.\nSkills and Qualifications\n5+ years designing and building optical microscopy instruments such as spinning-disk confocal or lightsheet systems, with at least one high-throughput microscope built end to end.\nStrong optical design and alignment skills, and hands-on optomechanical build experience (CAD and rapid prototyping a plus).\nPractical command of illumination sources, objective/optics selection, and cameras/detectors.\nAbility to code for instrument control, automation, and image processing and analysis.\nAbility to work collaboratively in a dynamic, fast-paced research environment.\nNice to have\nHigh-speed image-sensor integration, FPGA or custom data-acquisition electronics e\nExperience with the storage and data pipelines required for large-scale imaging.\nRepresentative projects\nBringing a prototype microscope to production and validating its performance on expanded tissue.\nScaling from a single validated instrument to a small fleet for large-scale acquisition.\nDeveloping robust mounting and handling for large expanded samples.\nSalary and Benefits\n$140,000–$200,000 base salary depending on experience, plus equity and benefits.\nOpportunity to work in a cutting-edge field that impacts neuroscience and AI safety.","company":"Eon Systems","rawCompany":"eon systems","city":"Millbrae","state":"CA","isRemote":false,"isActive":false,"createdAt":"2026-08-04T00:14:22.711Z","occupations":[{"code":"17-2199.06","title":"Microsystems Engineers","slug":"microsystems-engineers"},{"code":"17-2199.09","title":"Nanosystems Engineers","slug":"nanosystems-engineers"},{"code":"17-2199.00","title":"Engineers, All Other","slug":"engineers-all-other"}],"industries":[{"code":"541715","title":"Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)","slug":"research-and-development-in-the-physical-engineering-and-life-sciences-except-nanotechnology-and-biotechnology"},{"code":"541714","title":"Research and Development in Biotechnology (except Nanobiotechnology)","slug":"research-and-development-in-biotechnology-except-nanobiotechnology"},{"code":"334413","title":"Semiconductor and Related Device Manufacturing","slug":"semiconductor-and-related-device-manufacturing"}],"jobPosting":{"@context":"https://schema.org","@type":"JobPosting","title":"Senior Microscope Engineer","description":"About us\nEon is building the infrastructure for large-scale connectomics data collection, reconstruction, and brain simulation. Our mission is to enable the safe and scalable development of brain emulation technology, beginning with digital twins of model organisms.\nWe are developing an end-to-end platform that spans tissue preparation, high-throughput microscopy, large-scale image processing, neural reconstruction, connectome-based modeling, and embodied simulation. We are looking for exceptional engineers and scientists who can help turn biological brain data into usable computational systems.\nRole\nWe are seeking a Senior Microscope Engineer to build and scale the imaging systems at the heart of our connectomics pipeline. You will design, build, and bring up custom high-throughput optical microscopes optimized for imaging expanded brain tissue, take our current prototype through to a production-ready instrument, and lead its replication into a small fleet for large-scale acquisition.\nThis is a hands-on role for someone who has personally built high-throughput microscopes end to end — optics, optomechanics, illumination, detection, and control — and who is comfortable moving between instrument design, day-to-day acquisition, and the practical problem-solving that scaling a novel imaging system demands.\nResponsibilities\nDesign and build custom, cost-effective, high-throughput optical microscopes (e.g., spinning-disk confocal) optimized for expanded tissue.\nTake a working prototype to a production-ready instrument: motorized staging, optimized acquisition, and validated performance.\nOperate microscopes to acquire high-resolution 3D image volumes of expanded neural tissue, sustaining high throughput and high instrument uptime.\nProduce complete build documentation — bills of materials, budgets, timelines, and assembly SOPs a technician can follow — and lead replication toward a small fleet.\nTroubleshoot imaging issues and perform routine maintenance on microscopy equipment.\nSkills and Qualifications\n5+ years designing and building optical microscopy instruments such as spinning-disk confocal or lightsheet systems, with at least one high-throughput microscope built end to end.\nStrong optical design and alignment skills, and hands-on optomechanical build experience (CAD and rapid prototyping a plus).\nPractical command of illumination sources, objective/optics selection, and cameras/detectors.\nAbility to code for instrument control, automation, and image processing and analysis.\nAbility to work collaboratively in a dynamic, fast-paced research environment.\nNice to have\nHigh-speed image-sensor integration, FPGA or custom data-acquisition electronics e\nExperience with the storage and data pipelines required for large-scale imaging.\nRepresentative projects\nBringing a prototype microscope to production and validating its performance on expanded tissue.\nScaling from a single validated instrument to a small fleet for large-scale acquisition.\nDeveloping robust mounting and handling for large expanded samples.\nSalary and Benefits\n$140,000–$200,000 base salary depending on experience, plus equity and benefits.\nOpportunity to work in a cutting-edge field that impacts neuroscience and AI safety.","datePosted":"2026-08-04T00:14:22.711Z","dateModified":"2026-08-04T00:14:22.711Z","hiringOrganization":{"@type":"Organization","name":"Eon Systems","sameAs":"https://jobsearcher.com"},"jobLocation":{"@type":"Place","address":{"@type":"PostalAddress","addressLocality":"Millbrae","addressRegion":"CA","addressCountry":"US"}},"identifier":{"@type":"PropertyValue","name":"JobSearcher","value":"6805c883f6caa129308a372b"},"url":"https://jobsearcher.com/jobs/6805c883f6caa129308a372b"}}