{"schemaVersion":"jobsearcher.job.v1","id":"5b6b91cab28a5e052bebb33a","url":"https://jobsearcher.com/jobs/5b6b91cab28a5e052bebb33a","canonicalUrl":"https://jobsearcher.com/jobs/5b6b91cab28a5e052bebb33a","title":"Scientist –Viral Vector Process Development","description":"*Position Type: Scientist –Viral Vector Process Development*\n\n*Location: South San Francisco, CA*\n\n*Hourly rate: $48.00*\n\n*Contractor benefits: Medical, Vision, Dental, 401k*\n\n*Job Description:*\n\nScientist II – Viral Vector Process Development\n\nAdvance Next-Generation Gene Therapy Research\n\nWe are seeking a highly motivated and collaborative *Scientist II* to support the advancement of *lentiviral vector (LVV)* and *adeno-associated virus (AAV)* production platforms. This contract opportunity offers the chance to work alongside a cutting-edge research team focused on increasing viral vector throughput, improving yield, and accelerating support for discovery, screening, and pipeline programs.\n\nIf you have expertise in viral vector production, process development, automation, and data-driven optimization, this is an exciting opportunity to contribute to innovative therapeutic technologies and help drive scientific breakthroughs.\n\nKey Responsibilities\n\nViral Vector Process Development\n\n* Develop, optimize, and scale suspension-based *lentiviral vector (LVV)* upstream production platforms.\n* Design and execute experiments covering seed train expansion, shake flask production, and primary harvest activities.\n* Apply *Design of Experiments (DOE)* methodologies to optimize:\n* Multi-plasmid transient transfection conditions\n* Plasmid ratios\n* Transfection reagents (PEI, lipid nanoparticles, etc.)\n* DNA-to-cell ratios\n* Harvest timing and feed strategies\n* Chemical enhancers to improve packaging efficiency\n* Drive improvements in vector productivity, scalability, and process robustness.\n\nAutomation & High-Throughput Workflows\n\n* Implement and program automated liquid-handling systems such as *Integra Assist Plus*, *Bravo*, and similar platforms.\n* Support high-throughput applications including:\n* Transfection\n* Transduction\n* Sample preparation and dilution\n* Cell seeding\n* Integrate automated shaker arrays and micro-scale bioreactor systems (e.g., *Ambr 15* and *Ambr 250*) to execute parallel expression studies.\n* Troubleshoot automation workflows, liquid handling parameters, pipetting precision, and plasticware compatibility to reduce variability and improve consistency.\n\nDownstream Processing & Purification\n\n* Develop and optimize downstream manufacturing processes for viral vectors.\n* Evaluate and establish low-shear depth filtration and microfiltration strategies suitable for large-scale viral production.\n* Optimize ultrafiltration/diafiltration (TFF) and chromatography-based purification methods.\n* Support end-to-end process development from production through purification.\n\nViral Vector Analytics & Quality Control\n\n* Perform physical and functional characterization of LVV and AAV products.\n* Conduct analytical testing to assess critical quality attributes and support process optimization.\n* Integrate quality control data into upstream and downstream development workflows to rapidly identify improvement opportunities.\n* Ensure the delivery of high-quality viral vector materials to internal research teams.\n\nData Management & Scientific Documentation\n\n* Analyze complex process-development datasets using tools such as Excel, Prism, and AI-assisted analytical platforms.\n* Maintain organized viral vector inventories and digital tracking systems to ensure traceability and data integrity.\n* Author and maintain:\n* Standard Operating Procedures (SOPs)\n* Technical reports\n* Process development documentation\n* Technology transfer protocols\n* Present research findings and project updates at team and departmental meetings.\n\nRequired Qualifications\n\n* MS or PhD in:\n* Cell Biology\n* Molecular Biology\n* Virology\n* Biochemistry\n* Bioengineering\n* Genetics\n* Or a related scientific discipline\n* Minimum of *3 years of laboratory research or industry experience*.\n\nRequired Skills\n\n* Hands-on experience with mammalian cell culture and molecular biology techniques.\n* Proficiency in:\n* Transient plasmid transfection\n* PCR\n* qPCR\n* ddPCR/dPCR\n* Western blotting\n* Strong data analysis, interpretation, and presentation skills.\n* Direct experience with *ex vivo CAR-T cell engineering using lentiviral vectors* is required.\n* Excellent organizational, communication, and problem-solving abilities.\n* Self-motivated with strong attention to detail and the ability to manage multiple priorities.\n\nPreferred Qualifications\n\n* Experience with lentivirus and/or AAV production in adherent or suspension cell systems.\n* Expertise in viral vector process development and scale-up.\n* Knowledge of statistical DOE modeling and process optimization techniques.\n* Experience with automated liquid-handling technologies and laboratory automation.\n* Familiarity with flow cytometry operation and data analysis.\n* Experience using electronic laboratory notebooks (ELN).\n* Knowledge of BSL-2 laboratory operations and facility management.\n\n*Must be U.S. Person for purposes of Export Compliance. Reference Number: VEVBA*\n\n*EEO Statement Apollo Professional Solutions, Inc. is an equal opportunity employer. We provide equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, marital status, age, national origin, ancestry, disability status, medical condition, pregnancy, genetic information, protected veteran status, gender, sexual orientation, gender identity or expression, or any other status or characteristic protected under federal, state, or local law.*\n*#WCL*\n\nPay: $48.00 per hour\n\nBenefits:\n* 401(k)\n* Dental insurance\n* Health insurance\n* Vision insurance\n\nEducation:\n* Master's (Required)\n\nExperience:\n* Cell biology: 3 years (Preferred)\n* Biochemistry: 3 years (Required)\n* ex vivo CAR-T: 3 years (Required)\n\nWork Location: In person","company":"Apolloprofessionalsolutionsinc","rawCompany":"apolloprofessionalsolutionsinc","city":"Millbrae","state":"CA","isRemote":false,"isActive":false,"createdAt":"2026-10-29T10:46:53.039Z","occupations":[{"code":"19-1029.02","title":"Molecular and Cellular Biologists","slug":"molecular-and-cellular-biologists"},{"code":"19-1042.00","title":"Medical Scientists, Except Epidemiologists","slug":"medical-scientists-except-epidemiologists"},{"code":"19-1029.00","title":"Biological Scientists, All Other","slug":"biological-scientists-all-other"}],"industries":[{"code":"541714","title":"Research and Development in Biotechnology (except Nanobiotechnology)","slug":"research-and-development-in-biotechnology-except-nanobiotechnology"},{"code":"541715","title":"Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)","slug":"research-and-development-in-the-physical-engineering-and-life-sciences-except-nanotechnology-and-biotechnology"},{"code":"325414","title":"Biological Product (except Diagnostic) Manufacturing","slug":"biological-product-except-diagnostic-manufacturing"}],"jobPosting":{"@context":"https://schema.org","@type":"JobPosting","title":"Scientist –Viral Vector Process Development","description":"*Position Type: Scientist –Viral Vector Process Development*\n\n*Location: South San Francisco, CA*\n\n*Hourly rate: $48.00*\n\n*Contractor benefits: Medical, Vision, Dental, 401k*\n\n*Job Description:*\n\nScientist II – Viral Vector Process Development\n\nAdvance Next-Generation Gene Therapy Research\n\nWe are seeking a highly motivated and collaborative *Scientist II* to support the advancement of *lentiviral vector (LVV)* and *adeno-associated virus (AAV)* production platforms. This contract opportunity offers the chance to work alongside a cutting-edge research team focused on increasing viral vector throughput, improving yield, and accelerating support for discovery, screening, and pipeline programs.\n\nIf you have expertise in viral vector production, process development, automation, and data-driven optimization, this is an exciting opportunity to contribute to innovative therapeutic technologies and help drive scientific breakthroughs.\n\nKey Responsibilities\n\nViral Vector Process Development\n\n* Develop, optimize, and scale suspension-based *lentiviral vector (LVV)* upstream production platforms.\n* Design and execute experiments covering seed train expansion, shake flask production, and primary harvest activities.\n* Apply *Design of Experiments (DOE)* methodologies to optimize:\n* Multi-plasmid transient transfection conditions\n* Plasmid ratios\n* Transfection reagents (PEI, lipid nanoparticles, etc.)\n* DNA-to-cell ratios\n* Harvest timing and feed strategies\n* Chemical enhancers to improve packaging efficiency\n* Drive improvements in vector productivity, scalability, and process robustness.\n\nAutomation & High-Throughput Workflows\n\n* Implement and program automated liquid-handling systems such as *Integra Assist Plus*, *Bravo*, and similar platforms.\n* Support high-throughput applications including:\n* Transfection\n* Transduction\n* Sample preparation and dilution\n* Cell seeding\n* Integrate automated shaker arrays and micro-scale bioreactor systems (e.g., *Ambr 15* and *Ambr 250*) to execute parallel expression studies.\n* Troubleshoot automation workflows, liquid handling parameters, pipetting precision, and plasticware compatibility to reduce variability and improve consistency.\n\nDownstream Processing & Purification\n\n* Develop and optimize downstream manufacturing processes for viral vectors.\n* Evaluate and establish low-shear depth filtration and microfiltration strategies suitable for large-scale viral production.\n* Optimize ultrafiltration/diafiltration (TFF) and chromatography-based purification methods.\n* Support end-to-end process development from production through purification.\n\nViral Vector Analytics & Quality Control\n\n* Perform physical and functional characterization of LVV and AAV products.\n* Conduct analytical testing to assess critical quality attributes and support process optimization.\n* Integrate quality control data into upstream and downstream development workflows to rapidly identify improvement opportunities.\n* Ensure the delivery of high-quality viral vector materials to internal research teams.\n\nData Management & Scientific Documentation\n\n* Analyze complex process-development datasets using tools such as Excel, Prism, and AI-assisted analytical platforms.\n* Maintain organized viral vector inventories and digital tracking systems to ensure traceability and data integrity.\n* Author and maintain:\n* Standard Operating Procedures (SOPs)\n* Technical reports\n* Process development documentation\n* Technology transfer protocols\n* Present research findings and project updates at team and departmental meetings.\n\nRequired Qualifications\n\n* MS or PhD in:\n* Cell Biology\n* Molecular Biology\n* Virology\n* Biochemistry\n* Bioengineering\n* Genetics\n* Or a related scientific discipline\n* Minimum of *3 years of laboratory research or industry experience*.\n\nRequired Skills\n\n* Hands-on experience with mammalian cell culture and molecular biology techniques.\n* Proficiency in:\n* Transient plasmid transfection\n* PCR\n* qPCR\n* ddPCR/dPCR\n* Western blotting\n* Strong data analysis, interpretation, and presentation skills.\n* Direct experience with *ex vivo CAR-T cell engineering using lentiviral vectors* is required.\n* Excellent organizational, communication, and problem-solving abilities.\n* Self-motivated with strong attention to detail and the ability to manage multiple priorities.\n\nPreferred Qualifications\n\n* Experience with lentivirus and/or AAV production in adherent or suspension cell systems.\n* Expertise in viral vector process development and scale-up.\n* Knowledge of statistical DOE modeling and process optimization techniques.\n* Experience with automated liquid-handling technologies and laboratory automation.\n* Familiarity with flow cytometry operation and data analysis.\n* Experience using electronic laboratory notebooks (ELN).\n* Knowledge of BSL-2 laboratory operations and facility management.\n\n*Must be U.S. Person for purposes of Export Compliance. Reference Number: VEVBA*\n\n*EEO Statement Apollo Professional Solutions, Inc. is an equal opportunity employer. We provide equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, marital status, age, national origin, ancestry, disability status, medical condition, pregnancy, genetic information, protected veteran status, gender, sexual orientation, gender identity or expression, or any other status or characteristic protected under federal, state, or local law.*\n*#WCL*\n\nPay: $48.00 per hour\n\nBenefits:\n* 401(k)\n* Dental insurance\n* Health insurance\n* Vision insurance\n\nEducation:\n* Master's (Required)\n\nExperience:\n* Cell biology: 3 years (Preferred)\n* Biochemistry: 3 years (Required)\n* ex vivo CAR-T: 3 years (Required)\n\nWork Location: In person","datePosted":"2026-10-29T10:46:53.039Z","dateModified":"2026-10-29T10:46:53.039Z","hiringOrganization":{"@type":"Organization","name":"Apolloprofessionalsolutionsinc","sameAs":"https://jobsearcher.com"},"jobLocation":{"@type":"Place","address":{"@type":"PostalAddress","addressLocality":"Millbrae","addressRegion":"CA","addressCountry":"US"}},"identifier":{"@type":"PropertyValue","name":"JobSearcher","value":"5b6b91cab28a5e052bebb33a"},"url":"https://jobsearcher.com/jobs/5b6b91cab28a5e052bebb33a"}}