Medical Director, Clinical Research-Cardiology

Medical Director, Clinical Research-CardiologyAlnylam Pharmaceuticals is seeking an imaginative physician drug developer, with the flexibility and confidence to work in therapeutic areas that may be beyond their particular expertise or experience. This is an opportunity to provide clinical leadership in developing RNAi therapeutics in Alnylam's rapidly expanding portfolio, which spans from rare genetic to common diseases. The successful candidate's primary role will be as one of the clinical leads in a clinical development program in cardiology and/or cardiometabolic health. He/she will report directly into the program medical lead who provides the clinical research oversight of the program. The Director, Clinical Research is expected to play a leading and influencing role in the overall clinical development strategies for the molecules and drive progress and operational excellence for associated clinical trials. In addition, this role will include interaction with Alnylam's research group, helping to advise the team on the clinical development feasibility of novel targets and the design of proof-of-concept studies. This work will also involve extensive consultation and collaboration with external experts. It is expected that additional opportunities will arise to lead bench-to-bedside early phase clinical development programs. The Director, Clinical Research, will work in a matrix organization across Regulatory, Biostatistics, Clinical Operations, Preclinical, Commercial & Quality Assurance teams to ensure fully harmonized and integrated development strategies. The Director, Clinical Research will be a key Alnylam Development spokesperson at external meetings, including regulatory interactions and scientific meetings. This is a hybrid role with two days a week onsite presence based in our Cambridge, MA or Philadelphia, PA office.Key ResponsibilitiesBe the strategic leader providing a strong, clear voice for the clinical programDevelop creative but realistic approaches to drug development and lead clinical efforts to secure global regulatory approvalsOversight of trial conduct and safetyProvide strategic consultation and guidance to Research on all decisions that have significant clinical components and implicationsCollaborate closely with Preclinical, Regulatory Affairs and Medical Affairs to ensure tight strategic integration of product development plansBe accountable via Clinical Research and Operations for all relevant timelines and deliverablesSupervise closely all major written deliverables (regulatory submissions, original articles, abstracts), and presentation materialsBe responsible for final review and sign off with respect to all controlled documents including protocols, investigator brochures, and informed consent formsInfluence internal and external audiences in a high impact, highly visible fashionQualificationsA highly driven, dynamic, engaged and accomplished physician-scientist with experience and insight will thrive in this role.Specific qualifications include: MD with strong research background or MD PhD with best of class clinical and/or research training as shown through research support and peer-reviewed publicationsBoard Certification (or equivalent) or specialist training in cardiology or metabolic disease is desirable3+ years industry experience or equivalent clinical academic experienceSound scientific and clinical judgmentFamiliarity with concepts of clinical research and clinical trial design, including biostatistics, and regulatory agency organization, guidelines, and practicesAbility to effectively present ideas and document complex medical/clinical concepts in both written and oral communicationHistory of solving problems while exhibiting superior judgment and a balanced, realistic understanding of issuesOutstanding leadership and collaboration skills working within a matrix environmentExperience and knowledge of working with biotech/pharma partner(s)Thrives in highly entrepreneurial biotech environment and embraces Alnylam's culture of science, passion and urgency.U.S. Pay Range $255,000.00 - $345,000.00The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being.