Senior Director, Clinical Pharmacology

Senior Director, Clinical Pharmacology About DamoraDamora Therapeutics is an innovative biotechnology company that aims to fundamentally redefine care for people with hematologic disorders. We are advancing a new generation of biologics to treat mutant calreticulin-driven myeloproliferative neoplasms, including essential thrombocythemia and myelofibrosis, where there is significant medical need for new disease-modifying treatments. With multiple programs with best-in-class potential on track to enter clinical development in 2026, our goal is to rapidly bring forward optimized treatments with broad mutation coverage and exceptional convenience to dramatically improve patient outcomes.The RoleThis is a unique opportunity to join a science-driven company at a formative stage, where early clinical data will directly shape development strategy and drive long-term value. The right candidate will join a team with significant early- and late-stage development experience, with the goal of quickly moving through dose escalation/expansion into pivotal trials.The Senior Director, Clinical Pharmacology will lead Damora’s clinical pharmacology strategy and execution across all development programs and guide dose optimization, exposure–response modeling, and clinical pharmacology components of regulatory submissions. This role will work closely across development functions to shape integrated, forward-looking clinical development plans that support efficient and thoughtful program advancement.Responsibilities Develop and execute clinical pharmacology strategies across all stages of drug development Drive the integration of PK, PD, safety, and efficacy data to inform dose selection, dose modification, and labeling recommendationsAuthor and review clinical pharmacology sections of INDs, protocols, IBs and global submissionsRepresent clinical pharmacology in interactions with FDA and other global regulators, as requiredPartner closely with Clinical Development, Biostatistics, Regulatory Affairs, Translational Sciences, CMC and Bioanalytical teams serving as an subject matter expert in cross-functional discussions to ensure cohesive end-to-end development plansLead population PK (PopPK), PK/PD, exposure–response, and disease modeling analyses to inform clinical drug development using model-based approachStay current with global regulatory expectations for biologics to contribute to cross-functional strategyGuide quantitative pharmacology approaches supporting optimal dosing in patientsOversee CROs and external modeling vendors as needed Competencies Demonstrated ability to collaborate across matrixed, cross-functional teams in a fast-paced environmentProven ability to manage multiple projects simultaneously with attention to timelines and detailStrong communication and interpersonal skills; build trust and foster relationships internally and externallyAble to work independently, take initiative, and adapt quickly to evolving priorities.Recognized leader who exhibits effective communication, emotional intelligence, and influencing skills, within a matrix operating environmentDemonstration of strategic thinking and high-level planning while also balancing the ability to manage and execute operational detailsExperience designing clinical pharmacology and pharmacometrics components of filing packages and clinical studies across all phasesExperience with regulatory agency interactions including written responses and IND/CTA packagesQualifications PhD, PharmD, or MD in Clinical Pharmacology, Pharmacometrics, Pharmaceutical Sciences, Pharmacology, Translational Medicine, or related discipline with 10+ years of experience, OR Master’s Degree (or equivalent degree) in Clinical Pharmacology, Pharmacometrics, Pharmaceutical Sciences, Pharmacology, Translational Medicine or related discipline with 15+ years of relevant experience in biopharmaPrior experience with biologics development required.Experience in preclinical to Phase 1 stage programs required.Late-stage clinical development experience preferredExperience in oncology/hematology strongly preferredCompensation & BenefitsAt Damora Therapeutics, we offer competitive compensation and thoughtfully designed total rewards aligned with industry benchmarks. We believe in rewarding impact and building meaningful ownership for our team.Agency PolicyWe are building our team intentionally and do not accept unsolicited resumes from recruiting or staffing agencies. Agencies should not submit candidates unless directly engaged by Damora’s HR team and operating under a signed agreement. Any resume submitted without prior authorization and a signed agreement will be considered property of Damora Therapeutics, and no referral or placement fees will be paid.