Senior Director/Vice President, Clinical Development

Senior Director/Vice President, Clinical DevelopmentBoston, MA (Hybrid)FulltimeAbout UsDamora Therapeutics is an innovative biotechnology company that aims to fundamentally redefine care for people with hematologic disorders. We are advancing a new generation of biologics to treat mutant calreticulin-driven myeloproliferative neoplasms, including essential thrombocythemia and myelofibrosis, where there is significant medical need for new disease-modifying treatments. With multiple programs with best-in-class potential on track to enter clinical development in 2026, our goal is to rapidly bring forward optimized treatments with broad mutation coverage and exceptional convenience to dramatically improve patient outcomes.This is a unique opportunity to join a science-driven company at a formative stage, where early clinical data will directly shape development strategy and drive long-term value. The right candidate will join a team with significant early- and late-stage development experience, with the goal of quickly moving through dose escalation/expansion into pivotal trials.The RoleWe are seeking an experienced, hands-on Senior Director/VP of Clinical Development to lead the strategy and execution of our early phase clinical programs. This leader will oversee Clinical Development and key adjacent functions.This role is for a builder. You’ll design trials, author protocols, work with regulators, manage CROs, and guide programs through the clinic with speed and rigor. You’ll help shape the company’s clinical vision while executing day-to-day in a lean, fast-moving environment.This role reports directly to the Chief Medical Officer.What You’ll DoClinical Leadership & StrategyLead clinical strategy and execution for multiple Phase 1 programs.Drive trial design, protocol development, and clinical development plans.Provide medical and scientific leadership across global first inhuman trials.Functional Program OwnershipServe as Clinical Lead on cross functional program teams.Attract additional talent to build and scale the clinical organization.Regulatory & External EngagementLead clinical interactions with global regulatory agencies (FDA, EMA, TGA).Support preparation and delivery of IND/CTA filings and other regulatory submissions.Establish and grow strong KOL and investigator relationships in hematology and MPNs.Participate in external facing interactions, including investors, as a clinical subject matter expert.Execution ExcellenceProvide medical monitoring and safety oversight for ongoing studies.Contribute to vendor and CRO selection/management.Ensure executional discipline around timelines, budgets, and data quality.What You BringMD required.10+ years of industry experience in clinical development, including team leadership.Mandatory experience with early phase (FIH) trials.Experience in hematology and/or myeloproliferative neoplasms is strongly preferred (but not mandatory).Proven ability to lead both strategy and execution in a fast-paced environment.Ability to work effectively in a small, senior, highly collaborative team.Interest and readiness to grow into a future CMO role.Working ModelBoston-based is preferred but a hybrid, with regular presence required in the Boston area is possible for exceptional candidates.Relocation assistance and visa sponsorship are available for exceptional candidates.Compensation & BenefitsAt Damora Therapeutics, we offer competitive compensation and thoughtfully designed total rewards aligned with industry benchmarks. We believe in rewarding impact and building meaningful ownership for our team.Agency PolicyWe are building our team intentionally and do not accept unsolicited resumes from recruiting or staffing agencies. Agencies should not submit candidates unless directly engaged by Damora’s HR team and operating under a signed agreement. Any resume submitted without prior authorization and a signed agreement will be considered property of Damora Therapeutics, and no referral or placement fees will be paid.