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Extensive expertise in RNA, protein, and peptide analysis particularly in biopharmaceutically relevant contexts. Optimize and validate analytical and bioanalytical methods for the characterization of RNA molecules, including but not limited to purity, identity, integrity, and stability assessments.
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Molecular biology and biochemistry: RNA and DNA extractions, cloning, mutagenesis, quantitative PCR, protein immunoprecipitations, Western blotting, and proteomic sample preparation. The Buchwalter laboratory seeks a Junior Specialist to join the team at the Cardiovascular Research Institute on UCSF's Mission Bay campus.
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Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs). Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies.
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The key function of this lab-based role is to lead multiple steps in the manufacturing of RNA, including DNA production, RNA in vitro transcription, RNA purification and RNA analytics to support key preclinical studies of new RNA therapeutics.
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Robust experience in RNA sequencing (bulk and single-cell) and proteomics methods. We apply a multidisciplinary approach to our research and actively collaborate with virology, cell biology, genomics, proteomics, microscopy, and data science teams at the CZ Biohub San Francisco.
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Standard immunological techniques - Flow cytometry, ELISAs / Elispot, fluorescent microscopy Molecular biology skills - PCR, rt-PCR and RNA work, basic cloning Three published first authored papers in immunology.
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You will support R&D with single-cell and bulk RNA and DNA analysis and pipeline development while using and promoting best practices for coding (Python/R) and reproducible research. The Staff Scientist, Bioinformatics is responsible for collecting product requirements and designing and developing NGS analysis pipelines to meet those requirements.
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Work closely with RNA production, LNP/RNP formulation, and in vitro and in vivo team members. Characterize the RNA/RNP encapsulated LNPs for their size, zeta potential, morphology, encapsulation efficiency, integrity, and stability using relevant assays (DLS, TEM, Ribogreen, CE, AGE, PAGE, UV-VIS, HPLC, etc.
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Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD.
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The Regional Networking Automation (RNA) team plays a pivotal role in this mission by building software applications, services and tools to streamline the modeling and intent, design, development, deployment and operation of the OCI network data center and metro optical infrastructure.
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TCR repertoire analysis from DNA and RNA sequencing data. 4+ years of experience in computational biology for immuno-oncology applications (academic experience during PhD is counted). We are currently looking for a computational cancer biologist in the field of immuno-oncology to join our interdisciplinary team.
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The candidate will join the Process Science analytical team to study RNA folding computationally and experimentally for its CRISPR by Design platform. In-silico RNA structural modeling and alternative RNA structure ensemble deconvolution.
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The RNA Therapeutics Institute faculty are recognized as scientific trailblazers, and include a Nobel Laureate, a Gairdner Prize recipient, the 2018 RNA Society early and mid-career award recipients, two National Academy of Sciences members, a Fellow of the National Academy of Inventors, and three Howard Hughes Medical Institute Investigators.
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Perform analysis of in vitro and in vivo editing outcomes using next-generation sequencing, quantitative PCR, and RNA sequencing. Perform analysis of in vitro and in vivo editing outcomes using next-generation sequencing, quantitative PCR, and RNA sequencing.
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These tasks may include molecular biology assays such as PCR and cloning; mammalian cell culture experiments; flow cytometry assays; isolating RNA and performing qPCR; and mouse genotyping and assays in mice.
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rna job Title: specialist Company: Cibus
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