Perform cell culture including human neuronal cell lines and primary culture for mitochondrial protein and related complex enzyme activity, real-time PCR for quantification of gene expression and RNA array, gene silence for transcription.

Senior Scientist, Protein Engineer. + Skilled in reaching out and communicating with DARPA, DoD, and other government personnel, digesting basic and applied biotechnology research (and be able to apply this research to DoD capability gaps), and demonstrate a willingness to explore the scientific literature for emerging biotechnology.

Basic knowledge and skills in protein biochemistry and molecular biology are required. Perform large-scale protein purification techniques (such as protein expression, antibody screening, immunopurification, etc.

Industry giant seeks an experienced Process Development Scientist to develop protein purification processes to be scaled up and transferred into cGMP manufacturing including evaluation of transferred processes, transfer of processes to manufacturing, harvest clarification, normal flow filtration, purification, tangential flow filtration, and product final formulation.

Strong assay development skills in the areas of gene and protein expression, target engagement, signaling pathway read-outs, induced PPI and ternary complex formation. This effort will rely on the candidate to develop and apply a broad suite of assays which include various protein level assays, induced protein-protein interaction (PPI) assays, proteomics and proximity-labeling, as well as functional genomic screens, all with the goal of driving the discovery and development of novel monovalent degrader small molecules for targets across various disease areas.

The ideal candidate will have a solid background in protein purification and bioanalytical techniques used to characterize biologics. Quantify and characterize protein and antibody targets using typical analytical methods in protein chemistry.

The job requires experience with cell biology, molecular biology, and biochemistry, including molecular cloning, protein evolution, and screening, mammalian cell culturing, CRISPR genome editing, etc.

Candidate for this position must have prior experience in protein purification at preparative scales and demonstrated use of multiple protein purification technologies, such as IMAC, Size Exclusion, Ion Exchange, and HIC.

Solid background in protein chemistry, chemistry, biochemistry, toxicology or equivalent is highly preferred. Hands-on experience with instrumentation, used in protein pharmaceutical and analytical development as well as characterization and knowledge of cGMP and quality guidelines is a plus.

We are seeking a Postdoctoral Researcher Computational Biologist to join a dynamic, multidisciplinary project team focused on in silico design and evaluation of microbial gene and protein sequences.

We are seeking a talented Biochemist with experience in protein biochemistry. + Experience with various large scale protein purification techniques, protein expression, antibody screening and/or immunopurification techniques are desirable.

Position requires scientific and practical knowledge of protein chemistry or drug product process. Understanding of the basic principles of protein chemistry and/or drug product process is required.

This is an opportunity to leverage your expertise in sample preparation and enrichment techniques including protein and peptide immunoaffinity in conjunction with LCMS-based detection using high resolution and triple quadrupole MS. The measured parameters from preclinical studies or human specimens are input parameters to mechanistic models supporting target evaluation, dose, or efficacy projections.

Education: PhD in analytical chemistry, biophysics, biochemistry, engineering or related fields, with an emphasis on protein mass spectrometry strongly preferred. In this role, the Postdoctoral Fellow develops and implement various mass spectrometry-based methods to characterize complex biological systems especially with regards to protein structure.

Mass spectrometry, clia, protein analysis, cell culture, biomarker. mass spectrometry,clia,protein analysis,cell culture,biomarker. Participate in efforts of identifying, developing, and implementing innovative quantitative protein mass spectrometry technologies for proteomics across the oncology portfolio.