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Perform analysis of in vitro and in vivo editing outcomes using next-generation sequencing, quantitative PCR, and RNA sequencing. What you bring: PhD in biology, biochemistry, molecular biology, gene editing, or a related discipline and at least two years of closely related gene therapy or gene editing experience OR MS degree and five years directly applicable experience.
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PhD + 5 years' experience in toxicology or other closely related life sciences field, in the industrial or CRO setting, executing, or managing in vivo studies for the purpose of advancing a biological therapeutic candidate into the clinic (BS +11 years or Masters + 9 years will also be considered.
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PhD degree in Computational Neuroscience, Physics, Applied Mathematics, Bioengineering, or related field, highly preferred. The core responsibility for this position is to setup computational simulations and data analysis workflows from slice and in vivo brain physiology in humans.
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The successful applicant will drive rigorous scientific projects utilizing next-generation sequencing including single-cell RNseq and BCR-seq, molecular biology, antibody discovery and engineering, and in vivo animal modeling.
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A strong expertise in secreted proteins, protein engineering, and other modalities such as gene therapy mediated delivery, with hands-on experience in designing, characterizing recombinant proteins both in vitro and in vivo.
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Lead internal target selection, and validation (including assay development, compound screening, in vitro and in vivo pharmacology including in vivo PK/PD/efficacy models as well as additional studies (including toxicity) required to declare a compelling clinical candidate.
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He/She/They will be responsible for leading the screening and characterization of biotherapeutics and developing methods and new capabilities for in vivo pharmacology studies related to controlling neuromuscular impulse transmission and muscle movement.
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QUALIFICATIONS Education PhD in Molecular Biology, Neuroscience, or a related field Experience Cell culture and/or in vivo mouse experience Basic molecular biology Bioinformatics skills and experience handling high-throughput sequencing datasets is desirable but not required Attention to detail and the ability to work independently Collaborative and inclusive approach to science ABOUT US Our success will ultimately change healthcare.
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Work collaboratively and transversally to assist project team members in understanding toxicologic and pharmacologic relevance and implication of in vivo and in vitro study findings as necessary and assist in addressing queries from regulatory agencies.
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Hands-on experience establishing and optimizing in vivo pharmacology models and assays. Knowledge and experience in pre-clinical in vivo imaging (PET, SPECT, MRI, or CT) including understanding of theory and applying imaging to the study of disease in one or more therapeutic areas to study drug effects, biodistribution, and target engagement.
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Postdoctoral Associates will undertake creative and rigorous research including in vitro and in vivo approaches to investigate DNbased biological processes that allow novel, high resolution insights into the molecular mechanics of the cell.
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The ideal individual has a PhD in Biochemistry , Medicinal Chemistry, or Organic Chemistry and 15+ years of industry experience leading automation and high throughput biology/chemistry for target ID, Novel Hit Discovery, Hit to Lead, and Lead Optimization campaigns across multiple target classes and disease areas as a member of the senior leadership team of a small to mid stage biotech company or the R&D organization of a large pharmaceutical company.
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The Internal Medicine Research Unit (IMRU) is seeking a highly motivated non-PhD scientist with in vivo and molecular biology experience to support preclinical drug discovery efforts around obesity.
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Work closely with RNA production, LNP/RNP formulation, and in vitro and in vivo team members. PhD in biological sciences, chemistry, material science, bioengineering, chemical engineering, or related sciences with at least a year of relevant experience or MS with at least 8+ years of relevant experience.
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PhD in Bioengineering, Immunology, Molecular Biology, Biochemistry, Chemical Engineering, or a similar discipline. in vivo and in vitro procedures. Experience with in vivo bioluminescent imaging will be considered a distinct advantage, but not required (we will provide training.
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