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Knowledge of applicable complex scientific procedures and techniques, specifically with in-vitro and in-vivo model systems. Performs complex laboratory tests, determinations, and analyses involving multiple procedures and a variety of technical approaches, including those using in-vitro and in-vivo model systems.
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Working in this laboratory-based position within the Early Oncology Discovery group, you will develop, design, conduct, troubleshoot, and analyze in vitro experiments to validate tool reagents, investigate target biology, and dissect the mechanism of action of these novel cancer therapeutics.
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HD Biosciences, Inc. (US), a WuXi AppTec Company, is seeking a highly motivated and established Executive Director with deep and broad expertise in in vitro pharmacology including assay development, HTS/SAR, and compound management to join us.
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Major Roles and Responsibilities Conduct in vitro pharmacology experiments for preclinical contract research. iXCells Inc. (San Diego) is expanding its in vitro assay group. Hands experience on molecular biology, biochemistry, and cell biology techniques, such as molecular cloning, cell culture, DNA/RNA transfection, virus transduction, RNA isolation, real-time PCR, immunoblot, ELISA, MSD multiplex assay, cell viability assay, enzyme activity assay, etc.
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Ensure selection of appropriate in vitro and or in vivo methods and animal models to evaluate absorption, distribution, metabolism, excretion (ADME), and pharmacokinetic (PK) of radio-Theranostics drugs in GLP settings.
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The In-Vitro Diagnostic portfolio provides the golden standard of molecular based immunoassay technology for liver surveillance, cutting edge clinical diagnostic chemicals for leading laboratories across the country and diagnostic chemicals for OEM white labeling products.
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Developing plans for in-vitro biorelevant measurements (e.g., solubility/dissolution, IDR, permeability, transfer models for oral; in-vitro release methods for long-acting injectables and implants; SCISSOR model for subcutaneous modality) across projects and collaborating with partners (e.g., Materials Science, Analytical Development) to generate input data for modelling in-vivo product performance.
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Perform quantitative LC-MS/MS (Liquid Chromatography Mass Spectrometry) analysis of small molecules from various bio-matrices in vivo and in vitro to support PK/PD, ADME, efficacy, and exploratory toxicology studies.
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The preferred candidate should have extensive experience both in vitro and in vivo, including cell biology techniques such as culturing and/or engineering primary tissue cells and cell lines, in vivo techniques such as handling, dosing, dissecting and tissue harvesting of small experimental animals.
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The Scientist will be part of Century s Immunology / In-Vitro Pharmacology team and will be responsible for leading a small team. Lead in vitro pharmacology and/or immunology effort for therapeutic program.
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Position Title: Scientist/Sr. Scientist, Immunology & In-vitro Pharmacology. Hands on knowledge of advanced flow cytometry methods, including multi-color (8+ color) panel design and analysis, as well as ICC for phospho-flow, cytokine, transcription factor studies.
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Coordinate and participate in a variety of technical procedures to include in vivo and in vitro studies; operate radiation detection and measurement instrumentation including stationary imaging devices, scintillation gamma and apparatus for in vitro counting.
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The key function of this lab-based role is to lead multiple steps in the manufacturing of RNA, including DNA production, RNA in vitro transcription, RNA purification and RNA analytics to support key preclinical studies of new RNA therapeutics.
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Direct experience performing in vitro functional assays is preferred, including cytotoxicity, proliferation, multi-color flow cytometry and cytokine release. Execute in vitro and in vivo studies to support IND-enabling data packages.
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The successful candidate will have hands-on experience with cell-based in-vitro potency assays, SDS-PAGE, Automated Western blot assays, enzyme activity measurements, protein extraction, purification, and quantification methods.
$72,000 - $90,000 a yearFull-timeExpandApply NowActive JobUpdated Today
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