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Key Responsibilities: Lead preclinical studies that provide scientific rationale for advancement to human trials, including safety, efficacy, and mechanisms of action studies using clinically relevant in vitro and in vivo models.
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Position Summary The Executive Director of Neuroscience In Vivo Pharmacology and Translational Biomarkers is responsible for leading a group tasked with all aspects of generating in vitro and in vivo data used to develop pharmacokinetic / pharmacodynamic relationships, and the identification of translational biomarkers to support lead optimization and clinical development of PROTAC degrader molecules for severe neurologic disorders.
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Lead the design, development, and optimization of T-cell candidates using in vitro and in vivo assays. Expertise in developing and utilizing in vivo mouse models for preclinical evaluation.
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Responsibilities will include development and in vitro evaluation of drug delivery formulations - namely small molecule therapeutics and mRNA nanomedicines - and devices (~50% effort), and support preclinical evaluation of technologies in small and large animal models (~50% effort.
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Experience with current molecular biology techniques including in vitro transcription and translation, DNA/RNA extraction, PCR, and NGS. Collaborate closely with computational biology, gene editing and preclinical teams.
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Hands-on experience in designing, executing, and interpreting research, including protein sciences/engineering and immunology in vitro and in vivo pharmacology. · Lead early discovery research from target identification through preclinical assessment, including collaborations with other companies and academia.
ExpandApply NowActive JobUpdated 3 months ago - UpvoteDownvoteShare Job
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To meet the Program's distinct and growing needs, the successful candidate will be responsible for the management of in-vitro and in-vivo preclinical ADME/PK for novel drug candidates; supervising and managing students, post-doctoral researchers and research technicians.
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Analyze samples collected in preclinical in vivo studies to identify biomarkers in biofluids and surrogate tissues using biochemical methods including but not limited to ELISA, western blotting, qPCR, and/or immunohistochemistry (IHC.
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The postdoc in In Vitro Pharmacology/Discovery Biology research will participate in early-stage preclinical human disease model projects at Neurocrine. In collaboration with In Vitro Pharmacology- and Electrophysiology-team members the individual will be a key contributor to the development and implementation of a patient-specific organoid platform.
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Oversee the design, planning, and execution of preclinical studies, including in vitro and in vivo experiments, to evaluate the efficacy, safety, and mechanism of action of drug candidates.
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In vitro experience with cultured cell lines, siRNA transfection techniques, CRISPR, western blotting, quantitative PCR techniques, RNA/DNA isolation, scRNAseq, laboratory automation, high-content imaging technology, and fluorescence microscopy.
$131,588 - $150,335 a yearFull-timeExpandUpdated 5 days ago - UpvoteDownvoteShare Job
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Yourgene's flagship in vitro diagnostic products include non-invasive prenatal tests (NIPT) for Down's Syndrome and other genetic disorders, Cystic Fibrosis screening tests, invasive rapid aneuploidy tests and DPYD genotyping.
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Proactively identify key biopharmaceutics risks at each stage of drug product development for biologics and/or small molecules, conducting hypothesis-based assessment employing an integrated approach, driving the development of in vitro-in vivo relationships and preclinical-to-clinical translation in bioperformance of formulations.
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The Preclinical pharmacology team works closely with the Medicinal Chemistry, High Throughput Screening and Protein Engineering modules. Support complex scientific and research programs related to Molecular Pharmacology and Immunology; analyze data, monitor and oversee experimental processes, and design and develop novel in vitro and cell-based assay systems.
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The research lab conducts NIH-funded basic research pertaining to mechanisms underlying neurodegeneration and neuroinflammation in preclinical mouse models of Alzheimer's disease and related neurological disorders and traumatic brain injury.
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