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Mosaic teams provide comprehensive, end-to-end discovery services, including program assessment and strategy development; program management; antibody discovery and optimization; protein production, purification, and characterization; protein engineering; biochemical and cellular assay development; formulation, stability and developability studies; bioanalytical (PK and PD) assay development; and candidate-validating pharmacology.
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Lead preclinical pharmacology including in vitro and in vivo assay development and execution across the organization. Experience working with ion channels including manual and/or automated electrophysiology, heterologous expression systems, assay development and troubleshooting.
Full-timeExpandApply NowActive JobUpdated 15 days ago - UpvoteDownvoteShare Job
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Experience in oncology and assay development is highly desired. We are seeking a highly skilled and experienced Staff Program Manager to lead and coordinate the development of Research Use Only (RUO) and In Vitro Diagnostic (IVD) Software Products.
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We are seeking a highly motivated and talented scientist with background in cellular and molecular biology and assay development to join the Biotherapeutics and Genetic Medicine organization to support in vitro pharmacology work related to Genetic medicine research on AAV.
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HD Biosciences, Inc. (US), a WuXi AppTec Company, is seeking a highly motivated and established Executive Director with deep and broad expertise in in vitro pharmacology including assay development, HTS/SAR, and compound management to join us.
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Founded in late 2015, KSQ is a clinical-stage biotech that has rapidly advanced the field of CRISPR-enabled functional genomics, from in vitro cell autonomous screens to more complex genome-scale screens of immune cells in vivo.
Full-timeExpandApply NowActive JobUpdated 3 days ago - UpvoteDownvoteShare Job
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This is a customer-facing, customer-centric role and requires deep understanding of data management and flow in one (or more) scientific domains including process development, analytical chemistry, CMC, MAbs discovery, lab automation, protein production, in vitro screening, or assay development.
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Create and execute project plans for process and assay development and support the transfer of processes to cGMP manufacturing and quality control. Designs and produces viral vectors and characterizes them by performing varied in vitro and in vivo assays.
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Experience in assay development, mammalian cell culture, ELISA, Western blotting, qPCR, and experience in standard molecular biology techniques such as cloning, protein expression and purification is preferred.
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Operate and troubleshoot liquid handler automation and robotics for assay development. The successful candidate will join a fast-paced, highly productive, and innovative NGS Core team responsible for the expansion, refinement, and execution NGS analysis of in vitro and in vivo samples.
$90,000 - $144,650 a yearFull-timeExpandApply NowActive JobUpdated 5 days ago - UpvoteDownvoteShare Job
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Lead internal target selection, and validation (including assay development, compound screening, in vitro and in vivo pharmacology including in vivo PK/PD/efficacy models as well as additional studies (including toxicity) required to declare a compelling clinical candidate.
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Recently, a number of thyroid-related in vitro high-throughput screening (HTS) assays have been developed to broaden assay coverage for molecular targets potentially leading to thyroid disruption and were implemented to screen US EPAs ToxCast Phase 1, 2 and E1K libraries.
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Successful track record running in vitro and in vivo biology/pharmacology functions to drive small molecule programs from target selection (hit chemistry) to clinical proof-of-concept. Work with our AI/ML platform and Biologists to support efforts in Drug Discovery and Translational Biology, including demonstrating mechanisms of action then used to develop a biomarker and patient preselection strategy to aid clinical development.
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Applying innovative and cutting-edge approaches in in vitro to in vivo extrapolation and reverse toxicokinetics to translate effect concentrations measured in multi-well plates to equivalent blood, tissue, or environmental media concentrations.
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The successful candidate will receive an opportunity for career development that is as fast-paced as your ambition, all while gaining the opportunity to have a front-row seat at a dynamic and rapidly growing startup company, playing a key role in fundraising rounds.
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