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Knowledge of viral vector design (AAV, Lentivirus, Gamma retrovirus) and vector manufacturing processes. Familiarity with methods and systems used in biomanufacturing, essential molecular biology and methods such as PCR, purification, gel electrophoresis, sequencing, and high dimensional cell characterization approaches.
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An ideal candidate will have AAV purification experience, or broad recombinant protein and vector production experience, a collaborative spirit and a desire to work in a fast-paced startup environment.
$82,000 - $124,000 a yearFull-timeExpandApply NowActive JobUpdated Yesterday - UpvoteDownvoteShare Job
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Expertise in molecular biology including PCR, Golden Gate cloning, and other scarless vector construction methods and transformations. PT is a multidisciplinary team with broad capabilities in protein engineering, expression, purification, and characterization.
$115,546 - $135,957 a yearFull-timeExpandApply NowActive JobUpdated Yesterday - UpvoteDownvoteShare Job
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Additional skills include assay development, knowledge of DNA analysis software, such as Vector NTI, and experience with database management. Primary lab functions include protein expression, protein purification on a high-throughput platform, and molecular cloning.
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Responsibilities Design, optimize, and scale-up downstream processes for the purification of viral vectors, with a focus on AAV and lentiviral vectors. GeneFab is seeking a team-oriented Scientist II, Downstream Viral Vector Process Development to join GeneFab’s Viral Vector core to support the process development of novel cell and gene therapies.
$115,000 - $150,000 a yearFull-timeExpandApply NowActive JobUpdated 2 days ago - UpvoteDownvoteShare Job
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As a Manufacturing Associate, under the direction of the Lead, Associate Director or Director of Manufacturing, you will be responsible for executing either upstream or downstream operations for the production and purification of viral-based vectors for clinical use.
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Strong knowledge and experience in mammalian cell culture / bacterial fermentation / viral vector production operations (aseptic operations, cell biology, biochemistry, analytical techniques, bioreactor operations.
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1-5 years experience in viral vector/cell therapy (or biopharmaceutical) based GMP manufacturing operations including direct experience in cell culture, cell selection, recovery, purification, and/or aseptic fill/finish.
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Prior experience in/knowledge of cell culture, viral vector manufacturing, recovery and/or purification of viral vector product in a manufacturing environment preferred. The Assistant/Associate Scientist/Engineer to join our Vector and Gene Delivery MS&T group in GDPAD. The successful candidate will design and execute experiments related to supporting commercial vector manufacturing processes.
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Once the Houston facility has been established, the Manufacturing Specialist will be responsible for gene therapy product manufacture, performing all associated activities including: solution preparation, cell culture, purification, and fill finish.
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As part of a growing development team, the candidate will be required to perform activities across the team in addition to purification experiments (i.e. analytical characterization, bioreactor, and cell line.
Full-timeExpandApply NowActive JobUpdated 3 months ago - UpvoteDownvoteShare Job
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Responsibilities include management of all aspects of vector construction, cell culture, protein expression, protein purification, protein characterization, bioassay, in vitro and in vivo experimentation, daily measurement of experimental autoimmune encephalomyelitis, and other inflammatory disease models.
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Champion the advancement of the AAV viral vector production and purification platform through creative solutions including technology scouting and DoE experiments to accelerate gene therapy programs.
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Molecular biology including gene cloning, DNA fragment purification, ligation, gene vector construct and gene sequencing. Performing gene cloning, RNA extraction, qRT-PCR, DNA gel electrophoresis and purification, western-blot analysis, immunohistochemistry, etc.
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Familiarity with Next Generation Sequencing (NGS) Familiarity with protein engineering and/or mammalian cell expression. Experience with high throughput technologies, laboratory automation for liquid handling (e.g. Tecan, Hamilton, Bravo), and data management (e.g. LIMS systems, electronic laboratory notebooks.
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