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Abbott Molecular is a leader in molecular diagnostics and the analysis of DNA, RNA, and proteins at the molecular level. Our Point of Care diagnostic portfolio spans key heath and therapeutic areas, including infections disease, cardiometabolic, informatics and toxicology.
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Job DescriptionThe Director of Purification Development for Pre-pivotal Biologics will be responsible for leading molecular assessment, purification development, process transfer and implementation at manufacturing facilities to produce drug substances for toxicology and pre-pivotal clinical studies.
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A minimum of 3 years of related work experience developing and performing cell or molecular assay techniques (e.g., qPCR, dPCR, cytokine analysis, ELISA, PBMC isolation, flow cytometry). Doctoral degree in Molecular biology, Biochemistry, Immunology, Molecular Genetics, or related field.
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Develop Sales and Marketing insights using SAS/Python/SQL and operationalize these insights using Tableau/Power-Bi with Sales Tools Team and support the Tableau consumption layer for Sales and Marketing data.
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EPA Office/Lab and Location: A research opportunity is available at the Environmental Protection Agency (EPA), Office of Research and Development (ORD), Center for Computational Toxicology and Exposure (CCTE), Great Lakes Toxicology & Ecology Division (GLTED) located in Duluth, Minnesota.
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10+ years of experience working with IQVIA and/or Symphony Health data for enabling Commercial operations with Targeting, Alignment, Sales Compensation, CRM, and Analytics. Conduct data analytics using secondary data like Symphony/IQVIA/Komodo.
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Recently, a number of thyroid-related in vitro high-throughput screening (HTS) assays have been developed to broaden assay coverage for molecular targets potentially leading to thyroid disruption and were implemented to screen US EPAs ToxCast Phase 1, 2 and E1K libraries.
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With state-of-the-art technology and a commitment to excellence, we offer a comprehensive suite of tests ranging from toxicology and chemistry panels to molecular pathology and respiratory pathogen profiles.
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Experience in a biological science (e.g. Molecular/Cellular biology, Immunology, Toxicology, Pathology). Anatomic pathology and toxicology expertise across a wide-range of discovery and development activities in support of the portfolio.
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Applying innovative and cutting-edge approaches in in vitro to in vivo extrapolation and reverse toxicokinetics to translate effect concentrations measured in multi-well plates to equivalent blood, tissue, or environmental media concentrations.
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However, this screening approach leaves uncertainties regarding the meaning of in vitro activity data as it relates to in vivo outcomes. routinely used for testing thyroid disrupting chemicals, to understand whether, and how, in vitro activity of chemicals translates to in vivo outcomes.
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Using analytical chemistry methods to verify chemical concentrations, purity, and availability/partitioning in the test vessels. This battery of thyroid-related in vitro HTS assays can be employed to rapidly assess potential chemical toxicity toward these targets.
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The participants will learn to evaluate data quality, trouble shoot research results, apply statistical methods for data analysis and interpretation. Coordinated efforts will be undertaken in the mammalian model in parallel to these efforts to bolster cross-species concordance of modes of action and adverse outcome pathways (AOPs) related to thyroid disruption.
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Extensive experience in biologics manufacturability assessment, chromatography, TFF and viral filtration process development and scaleup. Ensure strong relationships with key stakeholder functions including Analytical Development, Cell Culture Development, Formulation Development, Research, Clinical Operation, and Program Strategy Teams by providing technical and strategic input.
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To that end, targeted in vivo testing will be performed using a model amphibian species (Xenopus sp.) Additionally, this research will employ existing computational tools such as the octanol-water partition coefficient (logKow) and quantitative structure-activity relationships (QSAR) models to provide deeper interpretation of in vitro data and further prioritize chemicals most likely to impact thyroid function in aquatic systems.
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