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Reporting to the Associate Director of Analytical Development, the Scientist will be responsible for the development of biophysical and analytical chemistry methods to further gene therapy products throughout clinical development, as well as performing BLenabling characterization studies.
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PhD in Analytical Chemistry, Biophysics, or related fields with experience in Analytical Development for biologics or gene therapy products. Develop methods to quantitatively measure the purity and heterogeneity of AAV gene therapy vectors, including empty capsid, aggregation, and capsid protein purity.
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With prior successful leadership in small molecule and/or peptide chemistry programs from Hit Identification to Development Candidate nomination is essential, you will be a subject matter expert in at least one of the following: pharmacology, assay development, cell and molecular biology or protein biochemistry to help support the growth and evolution of our platform as well as the Boston-based, early discovery team.
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Principal Scientist, Peptide Protein Chemistry. · Proficient in all aspects of modern peptide synthesis, protein bioconjugation, peptide and protein purification and analysis.
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3-5 years of analytical experience in protein/peptide separations by CE-SDS and/or cIEF in pharmaceutical or biotechnology company. B.Sc. degree in Chemistry, Biochemistry, Chemical Engineering, or related discipline.
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This role requires a PhD in Analytical Chemistry, Biochemistry, Chemical Engineering (or related field) with between 0-3 years of proven experience or a BS or MS with 10+ years in mass spectrometry and protein characterization (level will be commensurate with experience.
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Bachelor’s Degree in Chemistry, Biochemistry, Bioengineering, Chemical Engineering or. Our tools portfolio includes our proprietary, serum-free and protein-free, fully defined CryoStor freeze media and HypoThermosol shipping and storage media, ThawSTAR family of automated, water-free thawing products, evo cold chain management system, and Custom Biogenic Systems high-capacity storage freezers.
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Reporting to and partnering with the CEO, this role will lead a team of talented research scientists in Cancer Biology, Protein Therapeutics, Analytical Development, Pharmaceutical Chemistry, Formulation Development, Process Development and CMC Leadership for our Nemvaleukin alfa, IL-12 and IL-18 R&D programs.
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Investigate, explore, and implement state-of-the-art computational chemistry methods that potentially accelerate discovery of molecular glue. Employ cutting-edge computational chemistry methods, including physics/ML based activity prediction, QSAR, pharmacophore modeling and ADMET modeling to enable prospective design and propose design strategies.
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The candidate will have the opportunity to lead multi-disciplinary drug discovery and preclinical teams as targets progress and will be expected to work seamlessly with colleagues across discovery research, chemistry, preclinical pharmacology, toxicology and analytical development.
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Solid knowledge of medicinal chemistry principles, including DMPK, as well as the understanding of IP and its analysis is expected. Knowledge, Experience & Skills:Essential:Experience in a broad variety of computational techniques is essential, particularly molecular docking, pharmacophore development, library design and analysis, machine learning methods, and protein-ligand simulation.
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With its principal place of business in California, employs a world class team of engineers, scientists, clinicians, and manufacturing experts dedicated to the development and manufacture of point-of-care diagnostic devices using breakthrough microfluidics, protein engineering, and data/cloud connectivity.
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Demonstrated experience in mass-spectrometry method development for antibodies including LC-MS intact protein analysis, peptide mapping, conjugate analysis etc. Demonstrated experience in small molecule and protein mass-spectrometry of quantitation of antibody drug-conjugates (ADC), including total Antibody, Conjugated payload, and free payload.
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BA/BS degree in molecular biology, cell biology, biochemistry, protein chemistry or similar. Lead and manage of Chemistry, Manufacturing & Controls (CMC) components for products in early-to-late stage development including novels, biosimilars and cellular therapies.
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At 1910 Genetics, we put computation at the heart of drugdiscovery, blending expertise in computational chemistry, structuralbiology, pharmacology, genetics, data science, and softwareengineering to develop drugs for previously undruggable targets.
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