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PhD or MD/PhD in Molecular or Cellular Biology, Genetics, Pharmacology (or a comparable biological science) with 5+ years of relevant postdoctoral experience in an academic or pharmaceutical/biotech environment.
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Preparing room for behavioral testing of preclinical models of mood disorders and cognitive impairment, run behavioral tests, score behavior, analyze data Assisting scientists in mouse and rat handling, compound formulation, dosing (IP, PO, SC), and sample collection Maintaining good laboratory and safety practices, ensuring a clean and orderly environment.
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Additional Study-Related Activities: Contributes to the preparation of regulatory documents for IND filing (e.g., IND modules and ICF), collaborating with preclinical research functions (e.g., Pharmacology and Toxicology); prepares and presents material for first-in-human committees; prepares study reports, collaborating with Medical Writing; is responsible for or contributes to (in conjunction with a CRO medical monitor) study medical monitoring (MDs only.
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The successful candidate will use their strong in vivo pharmacology background and complementary laboratory skills to support discovery efforts and established pipeline projects with an emphasis on anti-obesity therapeutics.
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Work collaboratively in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to design promising clinical therapeutic candidates, flawlessly execute conduct of preclinical development studies, support clinical evaluation and contribute to IND and NDA filing.
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Sanofi is seeking an innovative investigative toxicologist to join our Preclinical Safety organization in a position that offers exciting and challenging scientific opportunities in a global environment.
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You will be responsible for oversight and interaction with consultants and CROs assigned to support clinical pharmacology tasks including preclinical PK, modeling, and clinical assay development.
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The Toxicologist will collaborate with external vendors, the internal preclinical pharmacology and toxicology team, and other stakeholders across the company to ensure efficient processes that scale with Verve's continued growth.
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Responsibilities will include development and in vitro evaluation of drug delivery formulations - namely small molecule therapeutics and mRNA nanomedicines - and devices (~50% effort), and support preclinical evaluation of technologies in small and large animal models (~50% effort.
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The scientist in this role will establish a preclinical immunoscience focused Quantitative Systems Pharmacology (QSP) capability to support discovery and early drug development efforts. This leader will be a part of a broader Quantitative Systems Pharmacology and Physiologically Based Pharmacokinetics organization with a strong intellectual environment and capable colleagues.
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Represent Preclinical development on discovery and development teams and regularly interfaces with internal and external colleagues to ensure timely and accurate dissemination of Safety Pharmacology and Toxicology findings.
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Keep up-to-date knowledge of model-based drug development with a focus on Clinical pharmacology, biopharmaceutics, PKPD & other related analytical sciences including implementation of innovative methods to preclinical research, translational sciences and clinical development.
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The Opportunity: As the leader of a cross-functional Cancer Pharmacology team, you will report into Executive Director and Head of Cancer Pharmacology in Translational Research: Be a critical contributor and provide strong strategic and technical leadership in translation research group and multi-disciplinary research and development project teams with a focus on preclinical modeling of combinations and resistance with an indication lens.
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The Preclinical pharmacology team works closely with the Medicinal Chemistry, High Throughput Screening and Protein Engineering modules. Preclinical pharmacology informs how drug candidates will behave in humans.
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University of Texas MD Anderson Cancer Center: Institute Associate Scientist II in Vivo Pharmacology
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The Associate Scientist II in Translational biology will be responsible for performing in vivo pharmacology studies to support preclinical development and translational biology of investigational therapeutics.
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