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Demonstrated expertise in, and leader of a team responsible for, in vivo pharmacology in preclinical models and translational human biomarkers using clinical samples. Guides team of scientists to build high-quality reliable ex vivo target engagement assays, pathway biology assays, and disease biomarker assays to support preclinical pharmacology studies.
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Lead and collaborate with project teams to develop in vitro pharmacology strategies and support Atomwise preclinical oncology programs. This role requires excellent communication skills, in-depth knowledge of preclinical cancer biology/pharmacology, and ability to design translational studies to support future clinical activities.
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They will interact daily with our data science and computational group for interpretation and design, our biology and pharmacology group to develop assay workflows for in vivo translation, and our chemistry group to push the boundaries of what is possible with parallel chemistry and library syntheses.
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The candidate will have the opportunity to lead multi-disciplinary drug discovery and preclinical teams as targets progress and will be expected to work seamlessly with colleagues across discovery research, chemistry, preclinical pharmacology, toxicology and analytical development.
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Provide in vitro biology and pharmacology support and collaborate with other drug discovery functions to advance preclinical programs and achieve company milestones. Collaborate closely with chemistry and ADME pharmacology teams in closed-loop lead optimization campaigns.
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Hands-on experience in designing, executing, and interpreting research, including protein sciences/engineering and immunology in vitro and in vivo pharmacology. · Lead early discovery research from target identification through preclinical assessment, including collaborations with other companies and academia.
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Interface with other specialists in medicinal chemistry, pharmacology, and translational medicine to ensure the successful delivery of drug candidates. Develop and execute the drug discovery strategy for natural products, including target identification and validation, hit identification and optimization, and preclinical candidate selection.
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Medical resource for design and interpretation of clinical and preclinical programs to support existing and new development candidates. Oversee the evaluation of safety, pharmacology, and efficacy data from ongoing and completed studies.
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Oversee the evaluation of safety, pharmacology, and efficacy data from ongoing and completed studies medicines in prostate cancer. MD, or,PharmD with BCOP certification and significant hospital-based experience, or, PA with substantial clinical oncology experience, or DO.
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Bachelor's degree in science (biology, chemistry, microbiology, immunology, medical technology, pharmacy, pharmacology), math, engineering, or medical fields. + Evaluate proposed preclinical, clinical and manufacturing changes for regulatory filing strategies.
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Responsibilities:Be a critical contributor and provide strong scientific and technical leadership in the translation research group with a focus on establishment, validation and characterization of complex preclinical disease models in vivo.
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Sanofi is seeking an innovative investigative toxicologist to join our Preclinical Safety organization in a position that offers exciting and challenging scientific opportunities in a global environment.
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Bachelor’s degree in science (biology, chemistry, microbiology, immunology, medical technology, pharmacy, pharmacology) math, engineering, or medical fields is preferred. Regulatory Affairs Specialist – Onsite in Lake Forest, IL.
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The In Vivo Pharmacology team at Kite Pharma FosterCity is seeking a Research Scientist to join an established group, to lead the development and characterization of in vivo murine models and associated ex vivo analyses for multiple cell therapy programs to address specific problematics related to engineered human chimeric antigen receptor T cells (CAR T cells.
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The Toxicologist will collaborate with external vendors, the internal preclinical pharmacology and toxicology team, and other stakeholders across the company to ensure efficient processes that scale with Verve's continued growth.
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