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Lead internal target selection, and validation (including assay development, compound screening, in vitro and in vivo pharmacology including in vivo PK/PD/efficacy models as well as additional studies (including toxicity) required to declare a compelling clinical candidate.
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Successful track record running in vitro and in vivo biology/pharmacology functions to drive small molecule programs from target selection (hit chemistry) to clinical proof-of-concept. PhD in Cell or Molecular Biology with over 10 years of biotech/pharma experience leading advancement of hit chemistry through DC selection, IND enabling studies and into clinical trials.
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Work with our AI/ML platform and Biologists to support efforts in Drug Discovery and Translational Biology, including demonstrating mechanisms of action then used to develop a biomarker and patient preselection strategy to aid clinical development.
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Expertise in oncology and ideally another therapeutic area (Autoimmune, rare disease, neuro) A strong understanding of both preclinical drug discovery and clinical translatability in oncology. Using our Discovery Platform, we are tackling the classically intractable targets, with an initial focus on Oncology and Rare Disease.
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The successful candidate will receive an opportunity for career development that is as fast-paced as your ambition, all while gaining the opportunity to have a front-row seat at a dynamic and rapidly growing startup company, playing a key role in fundraising rounds.
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Doctorate Degree (MD, PhD, VMD, or DDS) in biomedical sciences, immunology, pharmacology, or an area directly related to a field of research specialization in broad immunology and/or cancer biology.
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Proven abilities in developing robust data packages that generate clinically-testable precision medicine hypotheses. Please apply directly, or reach out to our Executive Search partners at Klein Hersh who are handling shortlisting.
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Extensive experience assessing and managing multiple CROs, establishing screening cascades and moving programs rapidly from discovery to preclinical to clinical development. Working with the CEO, you will be a key contributor to Serna Bios Program successes, leading from target selection to DC selection and IND filing into early clinical development, taking proactive and detail-oriented ownership of each step including the further build and development of relevant screening cascades, management of CROs and collaboration with external parties.
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Amgen Clinical Pharmacology Modeling and Simulation (CPMS) is seeking a Principal Scientist in our Thousand Oaks, CA location. Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 2 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience.
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Breadth of experience across different types of targets and mechanisms of action: transcription factors, undruggable targets and major drivers in oncology. However, 85% of the approximate 3 billion base pairs in the human genome encodes for RNA but not protein.
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The current toolkit for developing drugs is focused almost entirely on protein targets. We are looking for a Director of Biology to spearhead our programs and to take the lead on moving us towards DC selection, IND filing and clinical development.
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Collaborate with internal and external partners, key opinion leaders, CROs, biotech companies, translational and development groups. Serna Bio is building the worlds first map of the druggable transcriptome, systematically opening up the universe of RNA biology to small-molecule drug modulation.
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In this high-impact role, you will sit at the intersection of R&D and clinical and will be a vital resource as Serna Bio scales. Team leadership and mentoring skills and a desire to grow out your own function.
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Further, play a central role in planning and executing IND studies as well as contributing significantly to IND preparation and filing. The confidence and ability to exercise good judgment and decision-making in a variety of complex scenarios.
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We are a globally distributed, remote-first team headquartered in the United States. Ability to analyze, organize, summarize and articulate complex information and directions. Our mission is to develop a new class of drugs that will impact patient lives.
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