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You will use your knowledge and experiences in immuno-oncology to design and conduct experiments with the ultimate goal of make better medicines faster. Independently design, troubleshoot, and execute in vitro and ex vivo assays to narrow down promising hits from large antibody panels.
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Hands-on experience with preclinical models of cancer and immuno-oncology. In this vital role, you will be a part of a fast-paced, integrated, and interactive research group exploring therapeutics for immuno-oncology programs.
$98,093 - $114,246 a yearFull-timeExpandApply NowActive JobUpdated 2 days ago - UpvoteDownvoteShare Job
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We seek an energetic and motivated Scientist II to join our Immuno-Oncology team, which is aiming to redirect the immune system towards tumors by engineering hematopoietic cells in vivo.
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Broad knowledge in molecular and cell biology, immunology, especially in the immuno-oncology cell therapy field required. Design, execute, and interpret functional in vivo, in vitro, and ex vivo assays to understand the mechanism-of-action and play an active role in subsequent scientific discussions to drive decisions.
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Responsible for developing the Solid Tumor Oncology Diagnostic Sciences strategy for in vitro diagnostic (IVD) programs for immunohistochemistry, Immunoassay, PCR and NGS (tissue and blood based) including bioinformatics approaches.
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This comprehensive approach has resulted in a massive, experimentally derived dataset that we have found to be remarkably predictive of past successes and failures in oncology and immuno-oncology product development.
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Responsible for the development and execution of a range of Pharmacology studies including cell-based screening assays, immune cell bioassays, PK/PD assays and disease models for immuno-oncology, autoimmune and other in vivo immune-related disease models such as Tumor growth inhibition studies in humanized NSG tumor mice and autoimmune models.
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Must have oncology or immuno-oncology experience. 3-5 years of experience performing cell biology techniques: Mammalian cell culture, in vitro cellular assays (cell viability assay, proliferation, invasion, apoptosis), luciferase assay.
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2+ years of experience executing in vitro assays including cytotoxicity assays, flow cytometry, cytokine secretion. The successful candidate will have an immunology background, experience working with T-cells or other immune cells as well as the ability to execute in vitro assays to study human T cell biology.
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Experience in gene expression and signaling pathway analyses as well as mechanistic studies in immuno-oncology and immunology research a plus. Responsible for the development and execution of in vitro or ex vivo assays to characterize receptor binding, signaling, cell activation/suppression, and other functional readouts using a variety of techniques including flow cytometry-based assays, ELISA, and reporter assays.
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Preferred Education, Skills, and Knowledge 5+ years of immuno-oncology or immune mechanisms preferred. Experience with in vitro T cell functional assays, flow cytometry staining, and acquisition techniques is a plus.
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Bristol-Myers Squibb is actively conducting translational medicine research to further our understanding of cancer biology and to identify which patient populations may be more likely to derive benefit from Immuno-Oncology (I-O.
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Its Scientific Advisory Board includes Jim Allison (Nobel Laureate, Immuno Oncology), Bob Langer (MIT, co-founder Moderna), Phil Greenberg (Hutch, co-founder Juno), Pam Sharma (MD Anderson), Charlie Rudin (Sloan Kettering), Alan Ashworth (UCSF Cancer Center.
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You will lead a talented team, contributing to the discovery and development of novel therapies in Immuno-Oncology. In-depth knowledge of immuno-oncology, with a focus on developing therapeutic interventions.
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Quotient Therapeutics is seeking a Scientist with a strong immuno-oncology background, who will be responsible for the biology validation of novel oncology targets using in vitro and in vivo models.
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