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Essential for success., Cell culture, microbial fermentation, Chromatography design, use of QbD and. Must be a subject matter expert in microbial fermentation (yeast). fermentation and /or purification to develop robust, phase-appropriate processes for drug substance.
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The successful candidate will play a key role in advancing our understanding of plant cell culture processes, with a focus on molecular and cellular biology, genetics, and plant cell culture fermentation.
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Our client, one of the largest pharmaceutical companies in the U.S., is looking for an Engineer I which is located at Elkton, VA. The candidate will have a fundamental knowledge of fermentation and cell culture, protein chemistry and purification, analytical techniques and/or laboratory operations.
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Execute upstream manufacturing processes, including media preparation, cell culture maintenance, and fermentation operations, to achieve optimal plasmid DNA yields. Experience with cell culture techniques utilizing mammalian, bacterial, or insect cell lines.
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Upstream processes include tissue culture, cell bioreactors, fermentation, virus propagation, cell and virus bank production, and buffer/media preparation. Our innovative culture will allow interested candidates to discover and create, through collaboration, cutting edge solutions to tough problems.
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Evaluate culture purity, cell growth, and cell quality in the production seed train and primary fermentation. Meticulously execute Standard Operating Procedures, including checklists, for aseptically preparing sterile seed cultures for production fermentation, with culture sizes ranging from lab to production scale.
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Insight Global is seeking a Sr. Engineering Specialist for an Animal Vaccine R&D and manufacturing site in De Soto, KS. This position will be responsible for process development as it relates to fermentation, cell culture, proteins, and vaccines.
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This position will report to the Technical Operations Department and will support the manufacture of HPV Gardasil as part of a multidisciplinary team, the candidate will have a fundamental knowledge of fermentation and cell culture, protein chemistry and purification, analytical techniques and/or laboratory operations.
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Experience in a regulated, commercial GMP biomanufacturing environment (relevant experience may include media and buffer preparation, cell culture, fermentation, aseptic processing, chromatography, TFF, final formulation, and fill/finish.
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Scientific tasks include development and execution of experiments involving PCR, qPCR, in vitro fermentation, headspace gas chromatography, cell culture with rich or freshwater media, protein expression in bacteria, cell harvesting, protein characterization.
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Tasks to be completed may include fermentation, protein purification, solvent extractions, tissue culture, preparation of bulk solutions, aseptic fills of buffers, filling and labelling of vials under sterile and non-sterile conditions, routine buffer and media preparation, filtration, vial preparation, and sterilization.
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Strong experience within fermentation, cell culture, proteins and vaccines. This person will need come from a chemical or biological background with a strong understanding of working in a vaccine manufacturing environment regulated by the USDA. Other duties will include writing reports and protocol, coordinating meetings, and managing technical projects.
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Tasks to be completed may include fermentation, protein purification, solvent extractions, tissue culture, preparation of bulk solutions, aseptic fills of buffers, filling and labeling of vials under sterile and non-sterile conditions, routine buffer and media preparation, filtration, vial preparation and sterilization.
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The role will utilize plant cell culture to make compounds native to specific plants, just in a controlled fermentation approach and not the field. Proficient in molecular biology techniques, including PCR, qPCR, Western blotting, and gene expression analysis for plant cell culture.
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The Executive Director, Cell Culture and Fermentation Sciences position will be responsible for all aspects of upstream development and strategic direction to support the advancement of AstraZeneca’s (AZ’s) biologics pipeline projects from pre-clinical to commercial stage.
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