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GenScript ProBio is the subsidiary of GenScript Biotech Corporation, proactively providing end-to-end CDMO service from drug discovery to commercialization with proactive strategies, professional solutions and efficient processes in cell and gene therapy (CGT), vaccine, biologics discovery and antibody protein drug to accelerate drug development for customers.
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In addition, the lab identifies recombinant antibodies that bind to conformational states of enzyme, membrane proteins, protein complexes and other challenging targets. The Department of Pharmaceutical Chemistry is seeking a Junior/Assistant/Associate/Full Specialist in the Craik Lab. The Craik lab ( does chemical biology research with the intention of finding potent and specific enzyme inhibitors by studying the substrate specificity and structure of the enzymes.
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In the Kerfeld lab, postdoctoral research associate position is available involving protein/enzyme biochemistry, functional and structural characterization (including EM techniques, x-ray crystallography, x-ray footprinting), and synthetic biology-based approaches in vitro and in E. coli.
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Analysis may include immunological procedures including Enzyme Linked immunoassay (ELISA), Western blot, Flow Cytometry and RNA/DNA sequencing assays. Additionally, will perform molecular biology work including cloning, primer design, Gibson Assembly, restriction enzyme digestion, ligation, site directed mutagenesis, in vitro transcription, and reverse transcription.
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Prior experience involving the use of DNA manipulation, structure-function studies, and enzyme assays would be ideal. The lab's current projects focus on mechanistic studies of nucleotide excision repair and base excision repair protein interactions with damaged nucleotides in DNA and chromatin.
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Primary responsibility will be to complete research experiments involving enzyme activity assays, protein expression and purification, molecular biology, and/or tissue culture. Primary responsibility will be to complete research experiments involving enzyme activity assays, protein expression and purification, molecular biology, and/or tissue culture.
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The successful candidate will have hands-on experience with cell-based in-vitro potency assays, SDS-PAGE, Automated Western blot assays, enzyme activity measurements, protein extraction, purification, and quantification methods.
$72,000 - $90,000Full-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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GenScript's businesses encompass four major categories based on its leading gene synthesis technology, including operation as a Life Science CRO, enzyme and synthetic biology products, biologics development and manufacturing, and cell therapy.
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At least four of the following skills: Ribonucleic acid (RNA) and protein analysis, analytical gel electrophoresis, PCR, quantitative real-time RT-PCR, enzyme-linked immunosorbent assay (ELISA), western blot, flow cytometry, microscopy, histology/immunohistochemistry, histomorphometry, and cell/stem-cell culture maintenance, stem cell differentiation assays, cell-based assays, gene editing techniques, and/or biomaterials for drug delivery or tissue engineering.
$26 - $33 an hourExpandUpdated Today - UpvoteDownvoteShare Job
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Set up and run biochemical assays (protein, enzyme assays, etc.) , running ex vivo assays and with aspects of protein analysis (SDS-PAGE gels and western blotting). Perform analysis and interpretation of data from in vivo experiments, including presentation of data in spreadsheet and graphical form with descriptive statistical analysis.
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Essential: Hands on experience of using techniques such as ligand binding assays, GPCR assays , receptor tyrosine kinase assays, enzyme based kinetics and protein-protein interactions.
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Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women's Network, Working and Living with Disabilities.
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Experience with enzyme, protein isolation, centrifugation, and mixing processes is a plus. 3+ years of experience in industrial yeast wet processes, yeast extract, yeast fermentation, and spray-drying processes preferred.
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Experience with protein biochemical assay development, high-throughput screening, and enzyme kinetics (kinetic models, inhibition analysis, and assay troubleshooting). Design, execute, and oversee enzyme kinetic assays, protein binding assays, and biophysical analyses to support inhibitor characterization and small molecule discovery workflows.
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A strong understanding of method development and routine testing operations using the Protein Simple Jess - Capillary electrophoresis western blotting system. Support method development, transfer and qualification/validation activities associated with the cell-based potency assays for AAV-based gene therapy products.
$72,000 - $90,000 a yearFull-timeExpandApply NowActive JobUpdated Today
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