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Experimental responsibilities could include the following techniques: molecular biology (PCR, cloning), biochemistry (protein purification), bacterial directed evolution, zebrafish genome-editing, zebrafish line maintenance, antibody staining, RNA in situ analysis, high-resolution imaging, high-throughput larval behavior, adult behavior, cell culture maintenance, drug screens, and transcriptomics (bulk and single-cell RNseq.
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The faculty are internationally renowned for their strength in elucidating basic cellular and molecular mechanisms of signal transduction that lead to innovative drug target identification and ultimately to drug discovery.
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The ideal candidate brings expertise in functional assay development and molecular biology techniques with a passion for discovery and development of small molecule drugs. Work collaboratively in cross-functional teams with chemistry, proteomics, drug discovery and AI/machine learningEnsure rapid and accurate turnaround of data, to agreed timelines, to drive achievement of key project goals.
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Job SummaryWe are seeking a highly motivated Co-op with an interest in drug discovery and an entrepreneurial spirit to support our Cell Biology and Proteomics teams in Cambridge, Massachusetts.
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In Immunology, Molecular Biology, or related field with at least 8 years of applicable biomarker, translational research, program management, clinical trial and/or research experience is required Required Years of Related Experience: Strong background in tumor biology, project management, and laboratory management is required.
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Smithers PDS LLC (Pharmaceutical Development Services) assists in the development of new medicines by providing bioanalytical services for all phases of drug development from discovery through approval and post market surveillance.
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Per this strategic vision, we would like to further expand our research in Chemical Biology and complement current strengths in computational chemistry, drug discovery, and cancer research.
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Experience with molecular biology techniques, such as real-time PCR, sh/siRNA, ● M.S/B.S. with 4-10 years of drug discovery laboratory experience in academic/biotech. support progression of programs through all phases of drug discovery.
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The Department is strongly research-oriented with major programs in metabolism and metabolic regulation, cancer biology, parasite biology, carbohydrate biochemistry, chemical biology, chemistry and drug discovery.
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Must have proficiency in a range of cell/developmental biology, molecular, immunological, and genomic techniques, including experience in tissue culture, flow cytometry, DNA methylation analysis, and chromatin immunoprecipitation.
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Candidates should hold a Ph. D. or equivalent and be engaged in innovative research within biochemistry, molecular biology, or at the interface between chemistry and biology. We are particularly interested in strong candidates who wish to study molecular mechanisms of important biological processes and who will complement our existing strengths.
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Ph. D. or equivalent degree in a relevant scientific discipline (e.g., molecular biology, biochemistry, pharmacology, immunology) with a strong track record of scientific achievement. Proven expertise in drug discovery and development, with a deep understanding of the drug development process from target identification to IND filing.
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Preferred) Skilled at FACS, molecular biology, mammalian cell culture and assay development. (Required) Skill in molecular biology procedures such as DNA preparations, lentiviral packaging and infection of cells with virally packaged constructs.
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As a member of the small molecule drug discovery division, the successful candidate will leverage their advanced protein biochemistry skills to contribute to small molecule drug discovery programs and work collaboratively with cross-functional teams to further advance these innovative projects.
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PhD in Organic/Medicinal Chemistry, Chemical Biology, or a related field with more than 3 years of industry and postdoctoral experience in oligonucleotide drug discovery OR Master's degree with more than 6 years of industry experience OR Bachelor's degree with more than 8 years of industry experience is required.
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