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As an integral member of our multi-disciplinary drug discovery teams, you will direct investigative toxicology strategies to predict, assess and mitigate target- and modality-related safety risks in discovery programs.
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Advanced knowledge of statistical methods for evaluating in vitro and in vivo studies, assay development and characterization, biomarker discovery, digital biomarkers, etc.
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You will be responsible for providing, scientific leadership, and collaborative working environment to advance the drug candidates from IND through Phase IV. In addition, this position will collaborate with cross-functional stakeholders including in vitro & In vivo pharmacology, clinical biomarkers, DMPK, clinical development and operations, regulatory, CMC, and medical affairs.
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Serve as a leader supporting the overall CPP and/or translational medicine organizational objectives Stay current with scientific advancements and regulatory trends in clinical pharmacology and Pharmacometrics, and apply the knowledge to advance drug discovery and development for the organization; Publish in peer reviewed journals.
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Conduct/execute in vitro, ex vivo and/or in vivo studies to facilitate drug discovery and development with some independence. Experience in standard cellular and molecular biology techniques (Cell culture, ELISA, Cell-based assays, Immunofluorescence, Western blotting, Microscopy, RNA/DNA isolation, qPCR.
$65,000 - $78,000Full-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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The ideal individual has a PhD in Biochemistry , Medicinal Chemistry, or Organic Chemistry and 15+ years of industry experience leading automation and high throughput biology/chemistry for target ID, Novel Hit Discovery, Hit to Lead, and Lead Optimization campaigns across multiple target classes and disease areas as a member of the senior leadership team of a small to mid stage biotech company or the R&D organization of a large pharmaceutical company.
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In collaboration with AbbVie About the Role: Plays a key leadership role in developing our in vitro and in vivo strategies towards target identification and drug discovery, through to clinical candidate selection.
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The successful candidate will engage in innovative immune-oncology research, and contribute to every stage of pre-clinical drug discovery and development. The preferred candidate should have extensive experience both in vitro and in vivo, including cell biology techniques such as culturing and/or engineering primary tissue cells and cell lines, in vivo techniques such as handling, dosing, dissecting and tissue harvesting of small experimental animals.
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The successful candidate will work collaboratively with Translational Genetics and Discovery Chemistry to identify new therapeutic areas for application of the TRiM platform technology and develop appropriate in vitro and in vivo models for proof of concept studies and drug discovery activities.
$215,000 - $270,000ExpandApply NowActive JobUpdated 11 days ago - UpvoteDownvoteShare Job
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Work with our AI/ML platform and Biologists to support efforts in Drug Discovery and Translational Biology, including demonstrating mechanisms of action then used to develop a biomarker and patient preselection strategy to aid clinical development.
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In Cell and/or Molecular Biology or related discipline and 2 years of post-doctoral drug discovery experience in a biotech or pharmaceutical industry. in Cell and/or Molecular Biology or related discipline and 2-5 years of post-doctoral drug discovery experience in a biotech or pharmaceutical industry.
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The successful candidate will use their strong in vivo pharmacology background and complementary laboratory skills to support discovery efforts and established pipeline projects with an emphasis on anti-obesity therapeutics.
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Knowledge and experience in pre-clinical in vivo imaging (PET, SPECT, MRI, or CT) including understanding of theory and applying imaging to the study of disease in one or more therapeutic areas to study drug effects, biodistribution, and target engagement.
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Position Summary: The Senior Technician in the Discovery Technologies In vivo pharmacology group will be part of a dynamic group of scientists conducting various research projects to identify large molecule/biologics which can effectively treat various forms of cancer.
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As part of our mission, TRACTION is focused on partnering with our internal drug discovery engine (IACS, ORBIT, Biologics Development and Cell Therapies) and a growing list of external Partners (Boehringer Ingelheim, Taiho, Blueprint Medicines, Schr dinger and Obsidian) to discover and develop the next generation of small-molecule targeted therapies, antibody therapeutics and cell therapies, all driven by the needs we see in our patients.
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