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Biochemistry and/or molecular biology. biochemistry/biotechnology, biomedical sciences, cell biology, The current project aims to explore the contribution and regulation of the different downstream signaling outputs of IRE1 (XBP1 versus RIDD) in dendritic cells by focusing on an earlier identified mutation in the IRE1 kinase domain.
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The Senior Scientist is a part of the Downstream Bioprocess Development department and responsible for leading projects focused on developing, optimizing, and scaling purification processes for life science enzymes used in nucleic acid manufacturing and other applications.
$135,000 - $160,000 a yearFull-timeExpandApply NowActive JobUpdated 2 months ago - UpvoteDownvoteShare Job
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B.S. in Chemistry, Biology, Biochemistry, Biomedical Engineering, or related field with 0 years of experience required. Assess impact to both upstream and downstream processes when considering raw material, instrumentation/equipment, and process changes.
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Perform hands-on experimental work in the early-phase development and optimization of upstream (cell culture and transfection conditions) and downstream (clarification, chromatography, tangential and normal flow filtration) unit operations for viral vector production.
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BA/BS or MS in molecular biology, biochemistry, metabolism, or related field with 2-5 years of experience in drug discovery research. Supervise the execution of pharmacology studies at CROs and perform in-house downstream analysis to support drug discovery program needs.
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Experience in process development, more specifically in chemical conjugation is highly desired with a sound knowledge of organic chemistry and /or biochemistry, techniques like 1-D and 2-D NMRs, Mass spectroscopy, HPLC, HP-SEC-MALLS etc.
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Master of Science, Pharmacy, Pharmacology, Nutrition, Biochemistry or Biomedical science. Bachelor of Science, in Pharmacy, Pharmacology, Nutrition, Biochemistry or Biomedical science. Experience in Consumer Science/Products Research (qualitative & quantitative research, consumer modelling, upstream/front end consumer need definition AND downstream/product validation and claims substantiation.
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Exceptional Ph. D. in immunology, bacteriology, virology, molecular biology, biochemistry or biophysics ideally with industry experience. Additional skills to support downstream characterization as needed would be beneficial and could include: protein expression and purification using FPLC systems and biophysical characterization methods (SEC-MALS, DSF, and biosensor techniques including BLI and SPR.
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PhD in biochemistry, bioengineering or related field with 3-5 years of industry experience in downstream development. Provide managerial and technical leadership on all aspects of AAV purification to understand, characterize, and optimize the downstream process.
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Lead an integrated process development team across upstream and downstream functions for mRNA production. Ph. D. in Chemical/Biomedical Engineering, Biochemistry, or a related discipline with 8+ years of relevant industrial experience, M.S. with 10+ years, or B.S with 12+ years.
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3 + years of experience in Process Engineering related to biochemical engineering and/or protein biochemistry, scale-up principles and manufacturing of biologics (cGMP) + Upstream and/or Downstream process knowledge and hands on cell culture and/or purification pilot/clinical/commercial experience with regard to the manufacture of a biological drug substance.
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Understand the process control strategy (upstream/cell culture and downstream/purification) for biotech drug substance processes. in Biochemistry, Cell Biology, Biotechnology, Microbiology, Analytical Science, Biochemical Engineering, or related discipline.
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Hands on work will be required in small and large scale including, but not limited to, upstream, downstream, conjugation, formulation and lyophilization processes as needed. Masters degree in relevant field e.g. Biochemistry, Chemistry, Microbiology, Biotechniology, Bio-process technology, Immunology is required.
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Industry experience with early discovery and development of vaccines including optimization of upstream/downstream technologies that include benchtop fermentation, adjuvant selection and optimization, familiarity with in-process and potency assay design and development.
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Bachelors degree in Biology, Chemistry, Biochemistry, Chemical/Biological Engineering, or proven experience in a related Life Sciences field. Proven knowledge of upstream and/or downstream, as well as a general knowledge of the associated analytical, and solution preparation techniques (media and buffer.
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