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Support and closely work with research, cell-line development, upstream, downstream, and analytical scientist. The formulation scientist will work closely with downstream and analytical scientists to analyze biochemical and biophysical properties for biopharmaceutical products.
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Assist in implementation of new technologies to improve downstream purification production processes. We are seeking an Associate Scientist to join our Downstream Process Development group in Gaithersburg, MD. Qualified individuals will be responsible for hands-on execution of downstream chromatography and filtration processes in support of process development, scale-up, process characterization activities, and technical support of cGMP manufacturing for proteins, nanoparticles, and virus-like particle (VLP) based vaccines.
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Forte Protein Inc. is seeking a talented Research Associate for Microbial Fermentation Development with a passion for downstream processing, protein purification, and functional analysis.
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Experience with mammalian, insect, yeast, or bacterial cell lines and their cultivation and/or purification of biologics or viral vectors produced from such preferred. The Manufacturing Supervisor may be assigned to work directly with Upstream, Downstream or Buffer Preparation Unit Operations.
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The Senior Scientist I will play a key role in the developing downstream purification process development for various modalities such as mAbs, ADCs, bio-specifics, gene therapy, etc. Build experimentally verified fit for purpose mathematical models for downstream purification processes.
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A thorough understanding and working knowledge of the principles of purification and filtration processes is essential, with solid hands-on downstream process experience with chromatography systems, such as AKTA, and tangential flow (UFDF) filtration is required.
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Perform hands-on experimental work in the early-phase development and optimization of upstream (cell culture and transfection conditions) and downstream (clarification, chromatography, tangential and normal flow filtration) unit operations for viral vector production.
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Hands-on protein purification and downstream process development at scales from 0.1-50 L. Strong understanding of protein biochemistry as it applies to purification and enzyme characterization.
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Qualifications: B.S. in molecular biology, biochemistry, biophysics, immunology, or a related field with at least 1 year of experience Required: Hands-on experience in molecular biology skills including DNA preparation, quantification, agarose gel and sequence analysis.
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Development of upstream techniques and downstream purification of recombinant proteins. M.S. microbiology, biochemistry, chemical engineering, bioprocess engineering or a related field.
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The Senior Scientist is a part of the Downstream Bioprocess Development department and responsible for leading projects focused on developing, optimizing, and scaling purification processes for life science enzymes used in nucleic acid manufacturing and other applications.
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Job Overview: The 2023 Co-Op will work in the downstream process development group of the drug substance function in Specialty Care Manufacturing Science and Analytical Technology (MSAT). The co-op will work in a laboratory setting on a project related to protein purification process characterization and protein drug substance stability.
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Knowledge and experience with large scale protein purification, nucleic acid purification, and other chromatography application processes. Education: MS degree in biotechnology, analytical chemistry, material science, polymer science, chemistry, chemical engineering, biochemistry or related field.
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Through collaboration with industry partners, use scientific knowledge of molecular biology, biochemistry and purification techniques to support the advancement of novel cell and gene therapies, and to develop and optimise methodologies to deliver robust and scalable manufacturing processes.
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Perform hands-on work in a downstream purification lab, specifically column chromatography and filtration operations for vaccine production, process development, process characterization, and scale-up.
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