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Supports biochemical and cellular characterization of protein therapeutics for immuno-oncology. Develops, validates and executes biochemical and cell-based assays to characterize and screen biologic therapeutics in vitro and ex vivo, to support lead-finding/optimization efforts.
ExpandApply NowActive JobUpdated 8 days ago - UpvoteDownvoteShare Job
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Contribute to the project development as well as perform cellular immunological techniques, including multi-color flow cytometry, ELISA, MSD and in vitro immune cell assays. The Amgen Translational Immunology and Safety Sciences group based in South San Francisco, CA, is seeking a Principal Scientist to independently investigate immune related safety assessment with in vitro approaches and provide immuno-toxicological evaluation strategy to support Inflammation pipeline projects.
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The candidate is expected to have extensive immunology training and strong cellular immunology and cell culture technical skills. In this vital role you will supervise lab scientists, collaborate closely with toxicologists, pathologists, and scientists within the organization, and with multi-functional teams, perform literature-based evaluation and in vitro assays for various pipeline projects and present the work to cross-functional teams.
Full-timeExpandApply NowActive JobUpdated 8 days ago - UpvoteDownvoteShare Job
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Mosaic teams provide comprehensive, end-to-end discovery services, including program assessment and strategy development; program management; antibody discovery and optimization; protein production, purification, and characterization; protein engineering; biochemical and cellular assay development; formulation, stability and developability studies; bioanalytical (PK and PD) assay development; and candidate-validating pharmacology.
ExpandApply NowActive JobUpdated 5 days ago - UpvoteDownvoteShare Job
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Lead preclinical pharmacology including in vitro and in vivo assay development and execution across the organization. A PhD or equivalent with a focus on pharmacology, neuroscience, molecular biology, or cellular biology.
Full-timeExpandApply NowActive JobUpdated 16 days ago - UpvoteDownvoteShare Job
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Core areas of focus will be understanding the role of citrullination and other PTMs in the TDP -43 protein structure, biology, and pathology into both in vitro (induced pluripotent stem cell models) and in vivo systems (mouse models) to understand the clinical outcomes of TDP -43 pathogenesis in LATE and ADRD.
$56,484 - $63,852 a yearFull-timeExpandApply NowActive JobUpdated 6 days ago - UpvoteDownvoteShare Job
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We are seeking a highly motivated and talented scientist with background in cellular and molecular biology and assay development to join the Biotherapeutics and Genetic Medicine organization to support in vitro pharmacology work related to Genetic medicine research on AAV.
ExpandApply NowActive JobUpdated 2 days ago - UpvoteDownvoteShare Job
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The position will regularly overlap molecular, cellular, and in vivo biology with computational biology focusing on single cell RNA/DNA/Mitochondrial sequencing. We use several in vitro techniques, in vivo models, high resolution microscopy, single cell RNA/DNA/Mitochondrial sequencing to develop new strategies to answer relevant questions.
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Develop and conduct scientific experiments working with supervision and independently as projects develop including, but not limited to: Mouse studies Molecular cloning Gene editing and in vitro & in vivo genome wide CRISPR screening Virus production and delivery Develop new research protocols to characterize beta cell responses to cellular stress or autoimmune attack.
Full-timeExpandApply NowActive JobUpdated 7 days ago - UpvoteDownvoteShare Job
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The position requires: - Perform in vitro experiments using techniques including, but not limited to aseptic cell culture, molecular cloning, RNA isolation and PCR, western blotting and microscopy.
$18 - $23 an hourExpandApply NowActive JobUpdated 2 days ago - UpvoteDownvoteShare Job
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A Master’s or Bachelor’s degree in Molecular/Cellular Biology, Virology, Biochemistry or related field. · Plan and execute in vitro virology experiments under minimal supervision. Flow cytometry, fluorescent microscopy, suspension cell culture, lentivirus generation, SDS-PAGE and western blot, viral titering by TCID50, cell-based assays, ELISA, affinity chromatography, complement assays, Prism software.
ExpandApply NowActive JobUpdated 11 days ago - UpvoteDownvoteShare Job
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Direct experience performing in vitro functional assays is preferred, including cytotoxicity, proliferation, multi-color flow cytometry and cytokine release. Responsibilities include, but are not limited to:Execute in vitro and in vivo studies to support IND-enabling data packages.
$80,000 - $105,000 a yearExpandApply NowActive JobUpdated 2 days ago - UpvoteDownvoteShare Job
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Cell biology techniques: Mammalian cell culture, in vitro cellular assays (cell viability assay, proliferation, invasion, apoptosis), luciferase assay. Molecular biology techniques: DNA/RNA extraction, gene expression analysis (PCR/RT-PCR), western blotting, ELISA, Next Generation Sequencing, flow cytometry.
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Our laboratory is recruiting a postdoctoral fellow to use unbiased approaches (RNSeq, scRNSeq, spatial profiling, and flow cytometry) to identify novel molecular and cellular events in solid cancers with different treatments.
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Cellular and/or biochemical assays for antibody drug candidates screening, biological function evaluation in immuno-oncology and oncology drug discovery program. Mechanistic pharmacological analyses coupled with in vitro and in vivo evaluations using the syngeneic, transgenic and humanized mouse models, enables SparX’s focus on developing novel or best-in-class therapeutics demonstrating substantial advantages over existing therapies.
ExpandApply NowActive JobUpdated 6 days ago
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