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The leader will drive the development of highly productive robust commercial fed-batch and perfusion processes leveraging strong scientific principles in medium development, cell metabolism, bioreactor engineering, and design of experiment.
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In-depth knowledge and deep understanding of mammalian cell-culture processes including molecular biology & cell culture engineering concepts, media design, bioreactor scale-up, mass transfer, bioreactor control, single use and stainless bioreactor systems.
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They will also be a member of the Pivotal/Commercial Biologics Technical Development Leadership Team, that is responsible for providing leadership and decisions on the development and commercialization strategies for all aspects of late-stage process development (Cell Culture, Purification, Drug Product, Analytical Sciences, MSAT, and Materials Sciences.
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The Senior Associate Scientist will be a key contributor to the Pilot Plant Cell Culture group. The Senior Associate Scientist position is part of the Global MSAT Pilot Lab Cell Culture team in the drug substance function within global Manufacturing Science, Analytics and Technology (MSAT) and is based at the biologics hub in Framingham, MA. MSAT's mission is to enable the reliable supply of Specialty Care (SC) medicines by providing expert technical and scientific support to their licensure, ongoing commercial manufacturing, and life-cycle management activities.
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Extensive experience with small-scale and large-scale cell culture bioreactor process development. Optimize and scale-up fed-batch bioreactor processes, including evaluating different cell culture media and feed formulations.
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We are in search of a proficient and seasoned Manufacturing Manager or Supervisor with expertise in GMP (Good Manufacturing Practice) environments, particularly in overseeing cell culture and downstream processing operations.
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Knowledge of cell-line development for protein expression in mammalian systems and suspension cell culture. Knowledge of recombinant protein expression, metabolic pathways, biochemistry, and cell culture.
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Senior Associate Scientist, Cell Culture Process Development - Pre-Pivotal Biologics CMC Development – Foster City, CA. The Senior Associate Scientist, Cell Culture Process Development (Pre-Pivotal) will lead and execute cell culture process development laboratory experimentation for Gilead biologics entities during pre-pivotal phases development (pre-clinical, phase I/II.
$133,280 - $172,480Full-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Experience with mammalian cell culture perfusion bioreactor equipment setup and operation. Experience with pilot-scale (50L to 200L) mammalian cell culture upstream and downstream unit operations.
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You have a minimum of 3 years biopharmaceutical industry experience within upstream cell culture development or process development; MSAT, cGMP Manufacturing and/or Tech Transfer experience a plus.
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BPR&D includes three lab-facing technical functional areas: Process Cell Sciences (PCS), Upstream and Downstream Process Development & Engineering. Understanding of basic bioreactor principles, mass transfer kinetics.
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Ability to work with bioreactor operation and cell culture including aseptic technique. Bachelor’s degree in a Scientific, Engineering or Biotech field with 4 years’ experience with upstream (fermentation/bioreactor) biologic production processes under GMP compliance.
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Just – Evotec Biologics’ Bioreactor Process Development group is seeking an enthusiastic and hardworking team member who is passionate about expanding worldwide access to biotherapeutics through the advancement of continuous bioprocessing technology and mammalian cell culture processes.
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Bioreactor & cell culture experience. Duties include operation, maintenance, cleaning (CIP), and sterilization (SIP) of large-scale cell culture bioreactors and associated operations such as media preparation, infection, and harvest.
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Proficiency in bioprocess scale-up (fermentation or cell culture or equivalent) and expertise in developing and operating a variety of single-use and stainless-steel bioprocess equipment is required.
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